美托洛尔辅助胺碘酮治疗对冠心病合并室性心律失常患者疗效及B型利钠肽的影响

Effect of metoprolol assisted with amiodarone on patients with coronary heart disease complicated with ventricular arrhythmia and B-type natriuretic peptide

目的:探讨美托洛尔辅助胺碘酮治疗冠心病合并室性心律失常的临床疗效及对B型利钠肽的影响。方法:选取2022年5月至2023年5月期间本院心内科收治的88例冠心病合并室性心律失常患者。随机将患者分为对照组和研究组,每组各44例。对照组接受胺碘酮治疗;研究组接受美托洛尔辅助胺碘酮治疗。治疗7 d后分析比较两组的临床疗效、心功能、心律失常发作情况及B型利钠肽水平。结果:较之对照组,研究组临床治疗总有效率显著高于对照组(P<0.05)。治疗后,研究组的心排血量、每搏输出量、左室射血分数等心功能指标水平均显著高于对照组(P<0.05)。研究组的心律失常发作频率及B型利钠肽水平均显著低于对照组,心律失常单次发作持续时间显著短于对照组(P<0.05)。结论:美托洛尔辅助胺碘酮治疗冠心病合并室性心律失常,临床疗效显著,不仅可明显改善患者心功能及心律失常发作情况,还可显著降低B型利钠肽水平。

Objective:To investigate the clinical efficacy of metoprolol assisted with amiodarone in the treatment of coronary heart disease complicated with ventricular arrhythmia and its effect on B-type natriuretic peptide.Methods:From May 2022 to May 2023,88 patients with coronary heart disease combined with ventricular arrhythmia were selected from the cardiology department of our hospital.The patients were randomly divided into control group and study group,44 cases in each group.The control group received amiodarone treatment;The study group was treated with metoprolol adjuvant amiodarone.After 7 days of treatment,the clinical efficacy,cardiac function,arrhythmia onset and B-type natriuretic peptide levels of the two groups were analyzed and compared.Results:Compared with the control group,the total effective rate of the study group was significantly higher than that of the control group(P<0.05).After treatment,the levels of cardiac function indexes such as cardiac output volume,stroke output and left ventricular ejection fraction in the study group were significantly higher than those in the control group(P<0.05).The arrhythmia attack frequency and B-type natriuretic peptide level in the study group were significantly lower than those in the control group,and the single attack duration of arrhythmia was significantly shorter than that in the control group(P<0.05).Conclusion:Metoprolol assisted with amiodarone in the treatment of coronary heart disease complicated with ventricular arrhythmia has significant clinical efficacy,which can not only significantly improve the cardiac function and arrhythmia,but also significantly reduce the level of B-type natriuretic peptide.