经鼻高流量湿化氧疗对重症肺炎感染患者炎症反应的影响

Effect of nasal high flow humidified oxygen therapy on inflammatory response in patients with severe pneumonia infection

目的:探讨重症肺炎感染患者应用经鼻高流量湿化氧疗对炎症反应的影响。方法:选取80例本院2022年9月至2023年9月期间收治的重症肺炎感染患者为研究对象。根据随机数字表法将患者分为对照组和研究组,每组各40例。对照组接受经鼻持续气道正压通气治疗;研究组接受经鼻高流量湿化氧疗。治疗7 d后,收集两组患者临床资料,并使用统计学软件处理数据,分析比较两组治疗前、治疗后7 d炎症因子、血气分析指标水平以及并发症的发生情况。结果:较之对照组,研究组治疗后的C反应蛋白(C-reactive protein,CRP)、白介素-6(Interleukin-6,IL-6)、降钙素原(Procalcitonin,PCT)等炎症因子水平均显著降低(P<0.05)。研究组治疗后的呼吸频率(Respiratory rate,RR)水平比对照组显著降低,氧分压(Partial pressure of oxygen,PaO_(2))、氧合指数(Oxygenation index,OI)水平均比对照组显著提高(P<0.05)。两组治疗期间的并发症发生率无显著差异(P>0.05)。结论:经鼻高流量湿化氧疗应用于重症肺炎感染治疗,能减轻患者炎症反应,改善其血气分析指标,且并不会增加并发症发生风险,安全性较好。

Objective:To investigate the effect of nasal high-flow humidifying oxygen therapy on inflammation in patients with severe pneumonia infection.Methods:80 patients with severe pneumonia infection admitted to our hospital from September 2022 to September 2023 were selected as the study objects.According to random number table method,the patients were divided into control group and study group,with 40 cases in each group.The control group received nasal continuous positive airway pressure(CPAP).The study group received nasal high flow humidifying oxygen therapy.After 7 days of treatment,clinical data of the two groups of patients were collected,and statistical software was used to process the data,and the levels of inflammatory factors,blood gas analysis indexes and the occurrence of complications were analyzed and compared between the two groups before and 7 days after treatment.Results:Compared with the control group,the levels of inflammatory factors such as C-reactive protein(CRP),interleukin-6(IL-6)and procalcitonin(PCT)in the study group were significantly reduced after treatment(P<0.05).The respiratory rate(RR)level of the study group after treatment was significantly lower than those of the control group.The levels of partial pressure of oxygen(PaO_(2))and oxygenation index(OI)were significantly higher than those of control group(P<0.05).There was no significant difference in the incidence of complications between the two groups(P>0.05).Conclusion:The application of nasal high-flow humidified oxygen therapy in the treatment of severe pneumonia infection can reduce the inflammatory response of patients,improve the blood gas analysis index,and does not increase the risk of complications,and has good safety.