过敏性疾病与前列腺炎的因果分析:一项两样本孟德尔随机化研究

Causal analysis between allergic diseases and prostatitis:a two-sample mendelian randomization study

目的使用孟德尔随机化(MR)探索过敏性疾病与前列腺炎(Prostatitis)之间的因果关系。方法利用来自大型全基因组关联研究(GWAS)收集哮喘、湿疹、过敏性鼻炎、过敏、超敏和过敏性休克以及前列腺炎的数据,进行一项全面的两样本MR研究。研究中纳入欧洲患者人群数据,并采用逆方差加权(IVW)作为主要分析方法,而次级验证方法包括加权中位数、加权模式、MR-Egger回归和MR多效性残差和离群值(MR-PRESSO)检验来检测和校正多效性的存在。结果遗传学预期结局显示,哮喘(OR=0.27,95%CI=0.11~0.66,P=0.004)、湿疹(OR=0.44,95%CI=0.24~0.81,P=0.008)、与前列腺炎的发病呈负向因果效应。过敏性鼻炎(OR=0.23,95%CI=0.02~2.46,P=0.225)以及过敏、超敏和过敏性休克(OR=0.17,95%CI=0.01~2.10,P=0.165)与前列腺炎的发病风险无因果关联。同时在去除了与混杂因素关联的工具变量后,过敏性哮喘和湿疹的遗传倾向仍然与前列腺炎风险相关。结论本研究结果提供了证据支持过敏性疾病在前列腺炎发展中的因果作用,过敏性哮喘和湿疹与前列腺炎发病存在因果关联,而过敏性鼻炎、过敏、超敏和过敏性休克与前列腺炎的发病则没有因果关联。

Objective To explore the causal relationship between allergic diseases and prostatitis using Mendelian randomization(MR).Methods We conducted a comprehensive two-sample Mendelian randomization(MR)study using data on asthma,eczema,allergic rhinitis,allergy,hypersensitivity,and anaphylactic shock,as well as prostatitis from large genome-wide association studies(GWAS).The study included data from European patient populations and employed inverse variance weighting(IVW)as the primary analytical method.Secondary validation methods included weighted median,weighted mode,MR-Egger regression,and MR-PRESSO(Mendelian Randomization Pleiotropy RESidual Sum and Outlier)test to detect and correct for pleiotropy.Results The expected genetic outcomes showed that asthma(OR=0.27,95%CI=0.11~0.66,P=0.004)and eczema(OR=0.44,95%CI=0.24~0.81,P=0.008)exhibited a negative causal effect on the incidence of prostatitis.There was no causal association found between allergic rhinitis(OR=0.23,95%CI=0.02~2.46,P=0.225),allergy,hypersensitivity,anaphylactic shock(OR=0.17,95%CI=0.01~2.10,P=0.165)and the risk of prostatitis.After removing instrumental variables associated with confounding factors,the genetic predispositions of allergic asthma and eczema remained significantly associated with the risk of prostatitis.Conclusions Our findings provide evidence supporting a causal role of allergic diseases in the development of prostatitis.Allergic asthma and eczema have a causal association with prostatitis,whereas allergic rhinitis,allergy,hypersensitivity,and anaphylactic shock do not show a causal relationship with the incidence of prostatitis.