甲氨蝶呤治疗儿童急性淋巴细胞白血病的临床应用分析

Clinical application analysis of methotrexate in the treatment of children with acute lymphoblastic leukemia

目的从文献计量学角度分析甲氨蝶呤(MTX)治疗儿童急性淋巴细胞白血病(ALL)的相关文献,了解国内的研究现状及未来研究趋势。方法在中国知网数据库中检索国内MTX治疗儿童ALL的相关文献,用CiteSpace 6.1.R6 Advanced软件对文献的发文量、关键词共现、关键词聚类及关键词突现进行分析。结果共纳入205篇文献,发文量呈波动变化;MTX治疗儿童ALL研究热点主要为“大剂量”和“药物不良反应”,未来研究趋势围绕“基因检测”“药物监测”等展开。结论MTX在儿童ALL治疗中占有重要地位,MTX治疗儿童ALL的研究近些年集中于MTX的大剂量给药和药物不良反应。

Objective To analyze the literature on methotrexate(MTX)in the treatment of children with acute lymphoblastic leukemia(ALL)from the perspective of bibliometric analysis,and to understand the research status and future research trend.Methods Literature related to MTX treatment of children with ALL was retrieved from CNKI,and CiteSpace 6.1.R6 Advanced software was applied to the literature for trend of number of publications,keyword co-occurrence,keyword clustering and keyword emergence.Results A total of 205 literatures were included,and the number of published papers fluctuated.The main research hotspots of using MTX to treat children with ALL were“high-dose administration”and“adverse drug reactions”,and future research trends will focus on“gene detection”and“therapeutic drug monitoring(TDM)”.Conclusion MTX played an important role in the treatment of children with ALL,and research on MTX treatment for children with ALL focused on high-dose administration and adverse drug reactions of MTX in recent years.