大气压低温等离子体治疗慢性皮肤溃疡的作用机制

Mechanism of cold atmospheric plasma in treatment of chronic skin ulcer

目的对大气压低温等离子体(cold atmospheric plasma,CAP)在慢性皮肤溃疡治疗中的作用机制进行综述。方法广泛查阅近年来国内外使用CAP治疗慢性皮肤溃疡的研究文献,对CAP治疗原理、活性成分以及促进慢性溃疡愈合的作用机制进行总结。结果利用等离子体发生器在高电压下高频放电,即可电离气体产生含有电子、正负离子、氧自由基、氮自由基、紫外线等活性成分的CAP。体外和动物实验结果均显示,CAP的活性成分在慢性皮肤溃疡治疗中具有灭菌、抗生物膜、减轻炎症反应、改善组织灌注、加快组织增生和上皮形成的作用,通过多种机制促进溃疡愈合。结论CAP在慢性皮肤溃疡愈合的不同阶段均可发挥作用,具有很好的疗效和安全性,临床应用前景广阔,但需要更多研究探索CAP治疗的适应证和剂量。

Objective To review the mechanism of cold atmospheric plasma(CAP)in the treatment of chronic skin ulcer,providing a new idea for ulcer therapy.Methods The literature about CAP in the treatment of chronic skin ulcers in recent years was extensively screened and reviewed.The treatment principle,active ingredients,and mechanism were summarized.Results CAP is partial ionized gas discharged by plasma generator in high frequency under high voltage.It contains electrons,positive and negative ions,reactive oxygen species,reactive nitrogen species,and ultraviolet rays.In vitro and animal experiments show that the active ingredients contained in CAP can inactive microorganisms,against biofilm,regulate immune-mediated inflammatory,promoting blood flow,stimulate tissue regeneration and epithelial formation in the course of wounds healing.Conclusion CAP play a role in different stages of chronic skin ulcer healing,with good effectiveness and safety,and broad clinical application prospects.But more studies are needed to explore the indications and dosages of CAP therapy.