FT_(4)水平及FT_(4)/FT_(3),比值鉴别垂体性甲状腺功能减退和低T_(3)综合征的有效性研究

Efficiency of the FT_(4),level and FT_(4)/FT_(3),ratio in distinguishing pituitary hypothyroidism from low T_(3),syndrome

目的探索游离甲状腺素(FT_(4))水平及FT_(4)/游离三碘甲腺原氨酸(FT_(3))比值初步鉴别垂体性甲状腺功能减退(简称甲减)和低T_(3)综合征的有效性。方法收集2010年8月至2022年1月在北京朝阳医院住院的患者161例,其中垂体性甲减47例、低T_(3)综合征65例、甲状腺功能正常者49例。对比3组患者的FT_(4)水平及FT_(4)/FT_(3),比值的差异,应用ROC曲线分析FT_(4)/FT_(3),比值初步鉴别垂体性甲减和低T_(3),综合征的有效性,并确定最佳临界值。结果当FT_(4)<0.82ng/dL和(或)FT_(4)/FT_(3),比值<0.45时,诊断垂体性甲减的可能性较大。结论FT_(4)水平、FT_(4)/FT_(3),比值可以初步鉴别垂体性甲减和低T_(3),综合征。

Objective To explore the effectiveness of FT_(4)level and FT_(4)/FT_(3),ratio in the differential diagnosis of Pituitary hypothyroidism and low T_(3),syndrome.MethodsFrom August 2010 to January 2022,clinical data of 161 cases(including 65 cases of low T_(3),syndrome,47 cases of pituitary hypothyroidism and 49 cases of normal thyroid function)were collected from Beijing Chaoyang Hospital.The dferences in FT,level and FT_(4)/FT_(3),ratio among the three groups were compared.ROC curve analysis was used to analyze the FT_(4)level and FT_(4)/FT_(3);ratio to identify the effectiveness of pituitary hypothyroidism and low T_(3),syndrome,and to determine the best critical value.Results When FT<0.82 ng/dL and/or FT_(4)/FT_(3),ratio<0.45,the patient was more likely to be with pituitary hypothyroidism.Conclusion FT_(4)level and FT_(4)/FT_(3),ratio can preliminarily distinguish pituitary hypothyroidism from low T_(3)syndrome.