精准脉冲光联合1%吡美莫司乳膏治疗红斑毛细血管扩张型玫瑰痤疮的临床观察

Observation on the clinical efficacy of delicate pulsed light combined with 1%pimecrolimus cream in the treatment of erythema telangiectasia rosacea

目的 观察精准脉冲光(DPL)联合1%吡美莫司乳膏治疗红斑毛细血管扩张型玫瑰痤疮的临床效果。方法 选取2022年1月至2022年12月在漯河市第二人民医院皮肤科确诊的80例红斑毛细血管扩张型玫瑰痤疮患者,随机分为观察组(41例)与对照组(39例)。观察组采用DPL治疗,每4周1次,3次1个疗程,同时联合外用1%吡美莫司乳膏,2次/d,共12周;对照组仅外用1%吡美莫司乳膏2次/d,共12周。比较两组治疗后的疗效及不良反应。结果 治疗后第4、8、12周,观察组的皮损评分分别为9.26±1.86、7.91±1.87、5.95±1.46,明显低于对照组的11.38±1.36、10.67±1.64、8.67±1.35,差异有统计学意义(t值分为3.26、3.69、4.12,P值分别为0.002、0.001、0.001)。观察组有效率分别为29.27%、56.10%、73.17%,明显高于对照组的10.26%、28.21%、38.46%,差异有统计学意义(χ^(2)值分别为4.52、6.36、9.79,P值分别为0.034、0.012、0.002)。两组均未发生明显不良反应。结论 DPL联合1%吡美莫司乳膏治疗红斑毛细血管扩张型玫瑰痤疮临床疗效好,无明显不良反应,是一种有效、安全的方法。

Objective To investigate the clinical efficacy and safety of delicate pulsed light combined with 1%pimecrolimus cream for erythema telangiectasia rosacea.Methods Eighty patients with erythema telangiectasia rosacea were enrolled at the Second People′s Hospital of Luohe from January 2022 to December 2022 and were randomly divided into the observation(41 cases)and control groups(39 cases).The observation group was treated with 1%pimecrolimus cream twice daily for 12 weeks and DPL once every 4 weeks for 3 times.The control group was treated with 1%pimecrolimus cream alone.The therapeutic effects and adverse reactions were compared between the two groups.Results Following 4,8 and 12 weeks of the treatments,the skin lesion scores were 9.26±1.86,7.91±1.87 and 5.95±1.46,respectively,in the observation group and were 11.38±1.36,10.67±1.64 and 8.67±1.35,respectively,in the control group(t=3.26,3.69,4.12 and P=0.002,0.001,0.001 between the two groups).The effective rates were also differ significantly between the two groups at 4,8 and 12 weeks(29.27%vs.10.26%,56.10%vs.28.21%and 73.17%vs.38.46%,respectively.P<0.05 for all).No apparent adverse reactions were observed in either group.Conclusion DPL combined with 1%pimecrolimus cream is an effective and safe method for erythema telangiectasia rosacea.