摘要
阿尔茨海默病(AD)是一种以记忆和认知损害为主要特征的神经系统退行性病变,其发病机制尚未完全阐明,有研究发现AD的发生发展与单纯疱疹病毒1型(HSV-1)感染密切相关。HSV-1是一种常见的嗜神经病毒,可以通过促进β淀粉样蛋白(Aβ)沉积、tau蛋白过度磷酸化、氧化应激、神经炎症、载脂蛋白、自噬作用障碍等途径导致或加重AD,同时AD患者可能受益于抗HSV-1治疗。文中主要就AD与HSV-1感染的相关机制和治疗研究进展进行综述。
Alzheimer's disease(AD)is a neurodegenerative disorder characterized primarily by memory and cognitive impairment.Its pathogenesis has not been fully elucidated.Studies have found that the development and progression of AD are closely related to herpes simplex virus type 1(HSV-1)infection.HSV-1 is a common neurotropic virus that can lead to or exacerbate AD through various mechanisms,including promotingβ-amyloid(Aβ)deposition,tau protein hyperphosphorylation,oxidative stress,neuroinflammation,apolipoprotein dysfunction,and autophagy impairment.Additionally,AD patients may benefit from anti-HSV-1 treatment.The related mechanisms and therapeutic research progress on the association between AD and HSV-1 were reviewed.
作者
凤震海
李雨轩
李乃静
FENG Zhen-hai;LI Yu-xuan;LI Nai-jin(Department of Gerontology and Geriatrics,Shengjing Hospital of China Medical University,Shenyang 110004,China;China Medical University,Shenyang 110122,China)
出处
《中国临床神经科学》
2024年第4期463-468,共6页
Chinese Journal of Clinical Neurosciences
基金
中国医科大学附属盛京医院院内课题(项目编号:M1112)。
