TRAPPC家族在神经系统疾病中的作用研究进展

Research Progress on the Role of TRAPPC Family in Neurological Diseases

转运蛋白颗粒复合体(transport protein particle complex,TRAPPC)是一种多亚基复合物,参与构成TRAPP。TRAPPC家族在人体中参与囊泡转运、细胞自噬及糖基化等各种关键生理过程,对神经系统稳态至关重要。随着分子生物学领域的进步以及微阵列分析和下一代测序等高通量方法的广泛应用,遗传性中枢神经系统疾病的诊断变得更为准确,且TRAPPC家族成员在神经系统疾病中的重要作用得以进一步明确。该文综述了TRAPPC家族对神经系统发育和功能的影响及各亚基相关的神经系统疾病的研究进展,以期为相关神经系统疾病的临床治疗提供新思路。

The TRAPPC(transport protein particle complex) is a multi-subunit complex that is involved in the formation of TRAPP.The TRAPPC family is involved in various key physiological processes such as vesicle transport,autophagy,and glycosylation in the human,and is essential for nervous system homeostasis.With the advancement of the field of molecular biology and the wide application of high-throughput methods such as microarray analysis and next-generation sequencing,the diagnosis of inherited central nervous system diseases has been more accurate,and the important role of TRAPPC family members in neurological diseases has been further clarified.This article reviews the effects of the TRAPPC family on the development and function of the nervous system and the research progress of each subunit-related neurological disease,to provide new ideas for the clinical treatment of related neurological diseases.