老年T2DM病人甘油三酯葡萄糖指数与低密度脂蛋白亚型的关系研究

Correlation of triglyceride⁃glucose index with low⁃density lipoprotein subtypes in elderly patients with type 2 diabetes mellitus

目的观察老年T2DM病人甘油三酯葡萄糖(TyG)指数与LDL亚型的相关性。方法回顾性分析2022年1月至2023年3月间南京市江宁医院内分泌科收治的360例老年T2DM病人的临床资料,分析TyG指数与LDL亚型的相关性,并通过ROC曲线探讨TyG指数诊断高小而密低密度脂蛋白胆固醇(sdLDL-C)血症的界值。结果根据TyG指数四分位数将研究对象分组。TyG指数与LDL-C3、LDL-C4、LDL-C5、LDL-C6、LDL-C7均呈显著正相关(P<0.01),与LDL-C1和LDL-C2呈显著负相关(P<0.01)。Logistic回归分析显示,血清TyG指数与高sdLDL-C血症呈显著正相关。TyG指数预测高sdLDL-C血症发生风险的界值为9.0,AUC为0.70。结论在老年T2DM病人中,TyG指数与高sdLDL-C血症关系密切,可能成为识别sdLDL-C升高的简单易行的临床指标。

Objective To investigate the correlation between triglyceride⁃glucose(TyG)index and low⁃density lipoprotein(LDL)subtypes in the elderly patients with type 2 diabetes mellitus(T2DM).Methods The clinical data of 360 elderly T2DM patients admitted to Affiliated Jiangning Hospital of Nanjing Medical University from January 2022 to March 2023 were analyzed retrospectively.The correlation between TyG index and LDL subtypes was analyzed,and the cut⁃off value of elevated small dense low⁃density lipoprotein cholesterol(sdLCL⁃C)level was defined by receiver operating characteristic(ROC)curve analysis.Results All patients were divided into 4 groups according to the quartiles of TyG index level.The level of TyG index was positively correlated with LDL⁃C3,LDL⁃C4,LDL⁃C5,LDL⁃C6 and LDL⁃C7(P<0.01),and negatively correlated with LDL⁃C1 and LDL⁃C2(P<0.01).Logistic regression analysis showed a significant positive correlation between TyG index level and high sdLDL⁃C level.The cut⁃off value of TyG index to predict the occurrence of high sdLDL⁃C was 9.0,and the area under the curve was 0.70.Conclusions In the elderly patients with T2DM,TyG index is closely related to sdLDL⁃C level,which may be a simple and feasible clinical indicator to recognize the increase of the level of sdLDL⁃C.