^(99)Tc-MDP在大鼠血液中的药代动力学研究

Pharmacokinetics of ~(99)Tc-MDP in Rat Blood

为探究锝[^(99)Tc]亚甲基二膦酸盐注射液(^(99)Tc-MDP)在大鼠血液中的药代动力学特征,本研究采用电感耦合等离子体-质谱(ICP-MS)直接测定不同时间点^(99)Tc-MDP在大鼠血液中的含量,并用DAS2.1.1软件拟合药-时曲线,得出主要药代动力学参数。结果表明,^(99)Tc-MDP经尾静脉注射给药后,在大鼠血液中的药代动力学性质符合三室模型特征,分布相半衰期T1/2α为0.047 h,表明药物经尾静脉入血后在体内快速分布;消除相半衰期T1/2β、T1/2γ分别为0.113 h、37.349 h,表明药物自机体清除较慢。研究结果可为^(99)Tc-MDP在人体药代动力学方面的研究提供参考。

In order to investigate the pharmacokinetic characteristics of technetium [~(99)Tc]methylenediphosphonate injection(~(99)TC-MDP) in the blood of rats,the content of ~(99)Tc-MDP in the blood of rats at different time points was directly determined by inductively coupled plasma-mass spectrometry(ICP-MS),and the drug-time curve was fitted with DAS 2.1.1 software.The main pharmacokinetic parameters were obtained.The results showed that the pharmacokinetic properties of ~(99)Tc-MDP in the blood of rats were consistent with the characteristics of the three-chamber model,and the half-life of the distribution phase T1/2α was 0.047 h,indicating that the drug was rapidly distributed in the body after entering the blood through the tail vein.The elimination phase half-life T1/2β and T1/2γ were 0.113 h and 37.349 h respectively,indicating that the drug was cleared slowly from the body.The results can provide reference for the study of ~(99)Tc-MDP pharmacokinetics in human.