痛风患者血清髓过氧化物酶、白细胞介素-1β、转化生长因子-β1水平检测及其与尿酸水平相关性研究

Serum levels of myeloperoxidase,interleukin-1β,transforming growth factor-β1 and their correlation with uric acid in patients with gout

目的探讨高尿酸血症(HUA)伴痛风患者血清髓过氧化物酶(MPO)、白细胞介素-1β(IL-1β)、转化生长因子-β1(TGF-β1)水平变化,并分析其与尿酸水平的相关性及其交互作用。方法回顾性选取2019年12月至2022年12月在广西医科大学第十附属医院(钦州市第一人民医院)治疗的120例男性HUA患者作为研究对象,其中55例伴痛风患者为观察组,65例未伴痛风患者为对照组。比较两组血清MPO、IL-1β、TGF-β1水平,采用Logistic回归分析HUA伴痛风的危险因素,采用Pearson检验分析血清尿酸水平与MPO、IL-1β、TGF-β1水平的相关性,尿酸与其他指标的交互作用采用似然比检验进行计算。结果观察组血清尿酸、MPO、IL-1β、TGF-β1水平高于对照组[(559.63±70.62)μmol/L比(448.24±50.49)μmol/L、(0.37±0.10)mmol/L比(0.29±0.07)mmol/L、(49.83±5.03)ng/L比(42.15±4.77)ng/L、(34.15±6.82)μg/L比(28.97±5.14)μg/L],差异有统计学意义(P<0.05)。Logistic回归分析结果表明,血清尿酸、MPO、IL-1β、TGF-β1水平为HUA伴痛风的危险因素(P<0.05)。Pearson检验结果表明,HUA伴痛风患者血清尿酸水平与MPO、IL-1β、TGF-β1水平均呈正相关(r=0.760、0.775、0.759,P<0.05),且在HUA伴痛风发病中存在交互作用(P<0.05)。结论血清尿酸、MPO、IL-1β、TGF-β1高水平状态同时存在时可增加HUA伴痛风发生风险。

Objective To investigate the serum levels of myeloperoxidase(MPO),interleukin-1β(IL-1β)and transforming growth factor-β1(TGF-β1)in patients with hyperuric acid gout,and to analyze their correlation and interaction with uric acid.Methods A total of 120 male patients with hyperuricemia(HUA)diagnosed and treated in the Tenth Affiliated Hospital of Guangxi Medical University(Qinzhou First People′s Hospital)from December 2019 to December 2022 were selected as the study objects,including 55 patients with gout as the observation group and 65 patients without gout as the control group.Serum levels of uric acid,MPO,IL-1βand TGF-β1 were compared between the two groups,Logistic regression was used to analyze the risk factors of HUA with gout,and Pearson test was used to analyze the correlation between serum uric acid level and MPO,IL-1βand TGF-β1 levels,the interactions were calculated by the likelihood ratio test.Results The levels of serum uric acid,MPO,IL-1βand TGF-β1 in the observation group were higher than those in the control group:(559.63±70.62)μmol/L vs.(448.24±50.49)μmol/L,(0.37±0.10)mmol/L vs.(0.29±0.07)mmol/L,(49.83±5.03)ng/L vs.(42.15±4.77)ng/L,(34.15±6.82)μg/L vs.(28.97±5.14)μg/L,there were statistical differences(P<0.05).The results of Logistic regression showed that serum uric acid,MPO,IL-1βand TGF-β1 levels were risk factors for hyperuric acid gout(P<0.05).The results of Pearson test showed that serum uric acid were positively correlated with the levels of MPO,IL-1βand TGF-β1(r=0.760,0.775,0.759,P<0.05),and there was interaction in the pathogenesis of hyperuric acid gout(P<0.05).Conclusions The high levels of MPO,IL-1βand TGF-β1 at the same time can increase the risk of hyperuric acid gout.