加味黄芪六一汤联合卡格列净治疗气阴亏虚型糖尿病肾病临床观察

Efficacy observation of modified Huangqi Liuyi decoction and canagliflozin on diabetic nephropathy with syndrome of deficiency of qi and yin

目的:观察加味黄芪六一汤联合卡格列净治疗气阴亏虚型糖尿病肾病的临床疗效。方法:选取湖南中医药大学第二附属医院收治的糖尿病肾病患者60例,采用随机数表法分为两组各30例。对照组予卡格列净片口服,治疗组在对照组基础上予加味黄芪六一汤,疗程为3个月。观察两组临床疗效。结果:治疗组总有效率93.33%,明显高于对照组的73.33%,两组比较差异具有统计学意义(P﹤0.05)。治疗后,治疗组血糖指标、肾功能、24 h尿白蛋白定量、UACR、中医症状积分均明显优于对照组(P﹤0.05)。结论:加味黄芪六一汤联合卡格列净治疗气阴亏虚型糖尿病肾病疗效确切,可明显改善患者的肾功能。

Objective:To observe the clinical efficacy of modified Huangqi Liuyi decoction and canagliflozin on diabetic nephropathy with syndrome of deficiency of qi and yin.Methods:60 cases of patients with diabetic nephropathy who were treated in The Second Affiliated Hospital of Hunan University of Traditional Chinese Medicine were randomly divided into two groups,30 cases in each group.The control group was treated with oral canagliflozin tablets,while the treatment group was treated plus with oral modified Huangqi Liuyi decoction on the basis of control group.The course of treatment was 3 months.The clinical efficacy was observed in two groups.Results:The total effective rate of treatment group was 93.33%,which was significantly higher than 73.33%of control group,and the comparative difference between two groups was statistically significant(P﹤0.05).After treatment,the indexes of blood glucose,renal function,24-hour urinary protein quantity,UACR and TCM symptom score of treatment group were significantly better than those of control group(P﹤0.05).Conclusion:The clinical efficacy of modified Huangqi Liuyi decoction and canagliflozin on diabetic nephropathy with syndrome of deficiency of qi and yin is definite,which can significantly improve the renal function of patients.