脑类器官技术在小头畸形中的研究进展

Research progress of brain organoid technology in microcephaly

小头畸形是一种儿科常见的神经发育障碍疾病,病因复杂。近年来,随着脑类器官研究技术的发展,关于该技术在小头畸形发病机制及治疗策略等方面的研究进展迅猛。本文阐述了脑类器官相对于传统实验模型的优势,综述了脑类器官技术在多种病因导致小头畸形的疾病建模与药物筛选中的研究进展,并讨论了脑类器官存在的局限性和发展前景。

Microcephaly is a common pediatric neurodevelopmental disorder with complex etiology.In recent years,with the development of brain organoid technology,there has been rapid progress in understanding the pathogenesis and treatment strategies of microcephaly using this technology.This article elucidates the advantages of brain organoids over traditional experimental models,reviews the research progress of brain organoid technology in disease modeling and drug screening for various causes of microcephaly,and discusses the limitations and future prospects of brain organoids.