双相情感障碍缓解期患者及其一级亲属神经认知与听觉事件相关电位的关联研究

Associations Between Neurocognition and Auditory Event-Related Potentials in Remitted Patients with Bipolar Disorder and Their First-Degree Relatives

目的探索双相情感障碍(BD)的缓解期患者及其一级亲属认知损害和P300的异常特征及其关联。方法纳入2021年10月至2023年2月在厦门市仙岳医院精神医学科门诊及住院部的符合《精神障碍诊断与统计手册》第5版(DSM-Ⅴ)双相障碍Ⅰ型的诊断标准的缓解期患者40例,以及同期招募的41名未受影响的一级亲属组和35例健康对照组,采集所有受试者的人口学信息、临床资料以及认知功能评估和P3a/b振幅及潜伏期数据,比较三组间的认知功能及P3a/b成分的差异,并分析患者组异常的认知功能与P3a/b成分之间的关联。结果三组之间的P3a潜伏期、P3a振幅、P3b潜伏期和P3b振幅差异均有统计学意义(均P<0.05),BD患者P3a和P3b的潜伏期延长,振幅降低;三组之间数字符号测验、Stroop色词干扰测验(SCWT)-A和SCWT-C的得分差异有统计学意义均(P<0.05),而且在BD患者中,P3b潜伏期与SCWT-C得分呈负相关(r=﹣0.325,P<0.05)。结论双相情感障碍个体在缓解期间存在神经认知功能和P3a/b潜伏期和振幅异常,并且P3b潜伏期与异常认知之间的显著关联。

Objective The aim is to explore the abnormal characteristics of cognitive impairment and P300 in individuals with BD in remission and theirfirst-degree relatives,and to examine the potential associations between P3a/b amplitudes and cognition.Methods Forty patients with bipolar disorder typeⅠwho met the diagnostic criteria of Diagnostic and Statistical Manual of Mental Disorders,the fifth edition(DSM-Ⅴ)in the outpatient and inpatient departments of the Department of Psychiatry at Xianyue Hospital in Xiamen from October 2021 to February 2023,as well as 41 unaffectedfirst-degree relatives and 35 healthy control groups recruited during the same period,were included.Demographic information,clinical data,cognitive function evaluation,P3a/b amplitude and latency data of all subjects were collected.The differences in cognitive function and P3a/b components among the three groups were compared,and the association between abnormal cognitive function and P3a/b components in the patient group was analyzed.Results The differences in P3a latency,P3a amplitude,P3b latency,and P3b amplitude among the three groups were statistically significant(all P<0.05).The latencies of P3a and P3b in BD patients were significantly prolonged,and the amplitudes were significantly reduced.There were significant differences in the scores of digit symbol test,Stroop color word test(SCWT)-A,and SCWT-C among the three groups(all P<0.05).Moreover,in BD patients,there was a significant negative correlation between P3b latency and SCWT-C score(r=-0.325,P<0.05).Conclusions Ourfindings revealed deficits in neurocognitive function as well as latency and amplitude deficits in P3a/b in individuals with BD during the remission phase.Moreover,a significant correlation was observed between P3b latency and abnormal cognition.