研究丁苯酞注射液和依达拉奉右坎醇对急性缺血性脑血管病的疗效

Curative Effect of Butylphthalide and Edaravone Dexborneol in Acute Ischemic Cerebrovascular Disease

目的 研究丁苯酞注射液和依达拉奉右坎醇对急性缺血性脑血管病的疗效。方法 回顾性选取2022年1月—2024年2月吉林省四平市中心人民医院收治的86例急性缺血性脑卒中(acute ischemic stroke,AIS)患者的临床资料,按照不同用药方式分为对照组(采用丁苯酞注射液治疗)与研究组(采用丁苯酞注射液联合依达拉奉右坎醇治疗),各43例,对比分析两组患者临床疗效、神经功能状况。结果 治疗后,研究组患者治疗总有效率为95.35%(41/43),高于对照组的79.07%(34/43),差异有统计学意义(χ^(2)=5.108,P=0.024)。治疗前,两组患者中国脑卒中神经功能缺损评分(China Stroke Scale,CSS)及改良Rankin量表评分(Modified Rankin Scale,mRS)对比,差异无统计学意义(P均>0.05)。治疗后两组患者各项评分均显著降低,且研究组患者CSS及mRS评分低于对照组,差异有统计学意义(P均<0.05)。结论 在AIS患者的治疗中联用丁苯酞与依达拉奉右坎醇,可进一步改善患者神经功能损伤状况,疗效较好。

Objective To investigate the effectiveness of Butylphthalide Injection and Edaravone Dexborneol in acute ischemic stroke(AIS) treatment.Methods Clinical data from eighty-six patients with AIS admitted to Siping Central People's Hospital in Jilin Province from January 2022 to February 2024 were retrospectively selected.They were divided into a control group(treated with butylphthalein injection) and a study group(treated with butylphthalein injection combined with edaravone and dexmedetomidine) according to different medication methods,with forty-three patients in each group.The clinical efficacy,and neurological function status of the two groups were compared and analyzed.Results After treatment,the total effective rate of the study group was 95.35%(41/43),which was higher than 79.07%(34/43) of the control group,and the differences was statistically significant(χ^(2)=5.108,P=0.024).Before treatment,there were no statistically significant differences between the two groups in terms of the Chinese Stroke Scale(CSS) and Modified Rankin Scale(mRS) scores(both P>0.05).After treatment,the scores of both groups of patients significantly decreased,and the CSS and mRS scores of the study group were lower than those of the control group,the differences were statistically significant(all P<0.05).Conclusion In the treatment of AIS patients,the combination of butylphthalein and edaravone dexmedetomidine can further improve the neurological function damage of patients,and the therapeutic effect is good.