复方利多卡因乳膏在瘢痕疙瘩皮损内注射时的应用研究

Study on the Application of Compound Lidocaine Cream in the Injection of Keloid Skin Lesions

目的 探讨复方利多卡因乳膏在瘢痕疙瘩皮损内注射时的应用价值。方法 目的选取2022年7月—2024年2月常熟市第一人民医院收治的瘢痕疙瘩形成患者80例为研究对象。按照治疗方法不同分为两组,各40例。对照组使用曲安奈德混悬液,观察组则在给予曲安奈德混合液治疗前,先于瘢痕疙瘩局部使用复方利多卡因乳膏,比较两组麻醉起效时间及麻醉持续时间,分析两组治疗时疼痛评分及治疗后12 h瘙痒症状积分,统计两组麻醉后并发症。结果 观察组麻醉起效时间为(0.5±0.2)min,快于对照组的(1.6±0.3)min,麻醉持续时间为(25.8±2.4)min,长于对照组的(6.5±0.7)min,差异有统计学意义(t=19.295、48.826,P均<0.05);观察组治疗时疼痛评分及治疗后12 h瘙痒症状积分均低于对照组,差异有统计学意义(P均<0.05);两组发生局部感染、血肿形成及皮肤破溃的总发生率比较,差异无统计学意义(P>0.05)。结论 复方利多卡因乳膏可有效提高瘢痕疙瘩皮损内注射时的麻醉效果,延长麻醉时间,改善瘙痒症状,且并不增加并发症发生率。

Objective To explore the application value of compound lidocaine cream in the injection of keloid lesions.Methods Eighty patients with paralysis scar and pimple from July 2022 to February 2024 were objectively selected as the research object and were divided into two groups by different treatment methods,with forty cases in each group.The control group was given triamcinolone acetonide mixture injection,while the observation group was given triamcinolone acetonide mixture before treatment.The onset time and duration of anesthesia were compared between the two groups,and the pain score during treatment and the score of itching symptoms 12 hours after treatment were analyzed,and the postoperative complications of the two groups were counted.Results The onset time of anesthesia in the observation group was(0.5±0.2) min,which was faster than(1.6±0.3) min in the control group,and the duration of anesthesia was(25.8±2.4) min,which was longer than(6.5±0.7) min in the control group,the differences were statistically significant(t=19.295,48.826,both P<0.05).The pain score in the observation group and the itching score 12hours after treatment were lower than those in the control group,the differences were statistically significant(both P<0.05).There was no statistically significant difference in the total proportion of local infection,hematoma formation and skin ulceration between the two groups(P>0.05).Conclusion Compound lidocaine cream can effectively improve the anesthetic effect,prolong the anesthetic time,improve the itching symptoms,and does not increase the incidence of complications.