强直性脊柱炎患者血清PGLYRP-1、PTX3水平及其与炎症水平、骨密度的相关性

Serum levels of PGLYRP-1 and PTX3 and their correlation with inflammation level and bone mineral density in patients with ankylosing spondylitis

目的探讨血清肽聚糖识别蛋白1(PGLYRP-1)、正五聚蛋白3(PTX3)水平及其与强直性脊柱炎(AS)患者炎症水平、骨密度(BMD)的相关性。方法选取2021年1月至2023年1月该院收治的68例AS患者作为AS组,另选取同期健康体检者68例作为非AS组。检测所有研究对象血清PGLYRP-1、PTX3水平。采用Pearson相关分析AS患者血清PGLYRP-1、PTX3水平与炎症相关因子水平及不同部位处BMD的相关性。采用多因素Logistic回归分析PGLYRP-1、PTX3对AS发生的影响。结果AS组与非AS组工作状况、身高、身体质量指数、体质量、婚姻状况比较,差异均无统计学意义(P>0.05)。AS组红细胞沉降率、巴氏强直性脊柱炎疾病活动性指数评分、巴氏强直性脊柱炎功能指数评分均明显高于非AS组,差异均有统计学意义(P<0.05)。AS组PGLYRP-1、PTX3水平均高于非AS组,差异均有统计学意义(P<0.05)。AS组IL-1β、IL-6、IL-17、IL-18、TNF-α、CRP水平均高于非AS组,差异均有统计学意义(P<0.05)。AS组腰椎、股骨颈、华氏三角、股骨粗隆处的BMD显著低于非AS组(P<0.05)。AS患者血清PGLYRP-1、PTX3水平与IL-1β、IL-6、IL-17、IL-18、TNF-α、CRP水平均呈正相关(P<0.05)。AS患者血清PGLYRP-1、PTX3水平与腰椎、股骨颈、华氏三角、股骨粗隆处BMD均呈负相关(P<0.05)。多因素Logistic回归分析结果显示,PGLYRP-1、PTX3水平升高均是AS发生的独立危险因素(P<0.05)。结论AS患者血清PGLYRP-1、PTX3表达水平较高,与炎症因子水平的上升有关,且与患者不同部位BMD呈负相关,可能成为AS病情监测的有效标志物。

Objective To investigate the serum levels of peptidoglycan recognition protein 1(PGLYRP-1)and pentraxin 3(PTX3)and their correlation with inflammation level and bone mineral density(BMD)in patients with ankylosing spondylitis(AS).Methods A total of 68 AS patients admitted to the hospital from January 2021 to January 2023 were selected as the AS group,and 68 healthy subjects during the same period were selected as the non-AS group.The serum levels of PGLYRP-1 and PTX3 were detected in all subjects.Pearson correlation analysis was used to analyze the correlation of serum PGLYRP-1 and PTX3 levels with inflammatory related factors and BMD in different parts of AS patients.Multivariate Logistic regression was used to analyze the influencing of PGLYRP-1 and PTX3 on the occurrence of AS.Results There was no significant difference in working status,height,body mass index,body weight,and marital status between AS group and non-AS group(P>0.05).The erythrocyte sedimentation rate,AS disease activity index score and AS functional index score in AS group were significantly higher than those in non-AS group(P<0.05).The levels of PGLYRP-1 and PTX3 in AS group were higher than those in non-AS group,and the differences were statistically significant(P<0.05).The levels of IL-1β,IL-6,IL-17,IL-18,TNF-αand CRP in AS group were higher than those in non-AS group,and the differences were statistically significant(P<0.05).The BMD of lumbar vertebrae,femoral neck,Fahrenheit′s triangle and femoral trochanter in AS group were significantly lower than those in non-AS group(P<0.05).The serum levels of PGLYRP-1 and PTX3 were positively correlated with IL-1β,IL-6,IL-17,IL-18,TNF-αand CRP in AS patients(P<0.05).The serum levels of PGLYRP-1 and PTX3 were negatively correlated with BMD of lumbar vertebrae,femoral neck,Fahrenheit′s triangle and femoral trochanter in AS patients(P<0.05).Multivariate Logistic regression analysis showed that increased levels of PGLYRP-1 and PTX3 were independent risk factors for the occurrence of AS(P<0.05).Conclusion The expression levels of serum PGLYRP-1 and PTX3 are higher in AS patients,which are related to the increase of inflammatory factors,and negatively correlated with BMD of different parts of patients,which may be effective markers for disease monitoring of AS.