血清KLF2、S1P1水平与川崎病患儿冠状动脉损伤的相关性研究

The correlation between serum KLF2 and S1P1 levels and coronary artery injury in children with Kawasaki disease

目的探究锌指样转录因子2(KLF2)、1磷酸鞘氨醇受体1(S1P1)水平与川崎病患儿冠状动脉损伤的相关性,以及冠状动脉损伤发生的相关危险因素。方法选择华中科技大学同济医学院附属武汉儿童医院2021年12月—2023年12月收治的120例川崎病患儿作为研究对象,检测血清KLF2、S1P1水平,评估患儿是否存在冠状动脉损伤及其程度,分析血清KLF2、S1P1水平与冠状动脉损伤之间的关系。结果冠状动脉损伤患儿血清KLF2、S1P1水平低于无冠状动脉损伤[(2.48±0.72)pg/mL vs.(4.29±0.92)pg/mL;(287.65±42.88)ng/mL vs.(427.64±52.86)ng/mL,P<0.01];冠状动脉扩张组血清KLF2、S1P1水平高于小中型冠状动脉瘤组、巨大冠状动脉瘤组患儿,小中型冠状动脉瘤组血清KLF2、S1P1水平高于巨大冠状动脉瘤组患儿;血清KLF2、S1P1水平与冠状动脉损伤程度呈负相关关系(r=-0.522、-0.634,P=0.003、<0.001);多元logistic回归分析,结果显示发热病程、白细胞计数、KLF2、S1P1均为患儿冠状动脉损伤的影响因素(P<0.05)。结论川崎病冠状动脉损伤患儿血清KLF2、S1P1水平下降,且下降程度与冠状动脉损伤程度密切相关,发热病程、白细胞计数、KLF2、S1P1水平是患者冠状动脉损伤的影响因素。

Objective To explore the correlation between Krüppel-like transcription factor 2(KLF2)and sphingosine 1-phosphate receptor 1(S1P1)levels and coronary artery injury in children with Kawasaki disease,and the risk factors for coronary artery injury.Methods A total of 120 children with Kawasaki disease admitted to Wuhan Children' s Hospital,Tongji Medical College,Huazhong University of Science and Technology from December 2021 to December 2023 were studied.Serum KLF2 and S1P1 levels were determined,the presence and the degree of coronary artery injury were as-sessed,and the correlation among serum KLF2,S1P1 levels,and coronary artery injury was analyzed.Results The levels of serum KLF2 and S1P1 in children with coronary artery injury were lower than those without injury[(2.48±0.72)vs.(4.29±0.92)pg/mL,(287.65±42.88)vs.(427.64±52.86)ng/mL,P<0.01];The levels of serum KLF2 and S1P1 in coronary dilatation group were higher than those in small,medium and large coronary aneurysm group;The levels of serum KLF2 and S1P1 in the small and medium coronary aneurysm group were higher than those in the large coronary aneurysm group;Serum KLF2 and S1P1 levels were negatively correlated with the degree of coronary artery inju-ry(r=-0.522,-0.634;P=0.003,P<0.001);Multiple Logistic regression analysis showed the duration of fever,white blood cell count,KLF2 and S1P1 were the influencing factors of coronary artery injury in children(P<0.05).Conclusion The levels of serum KLF2 and S1P1 in children with Kawasaki disease with coronary artery injury decrease,and the decreased degree is closely related to the degree of coronary artery injury.The course of fever duration,white blood cell count,and the levels of KLF2 and S1P1 are influential factors for coronary artery injury.