维持性血液透析患者血清细胞分裂周期蛋白42、β_(2)微球蛋白、腓骨蛋白1水平与腹主动脉钙化的相关性

Correlations of serum cell division cycle 42,β_(2)-microglobulin and fibulin 1 levels with abdominal aortic calcification in patients with maintenance hemodialysis

目的 探讨维持性血液透析(MHD)患者血清细胞分裂周期蛋白42(CDC-42)、β_(2)微球蛋白(β_(2)-MG)、腓骨蛋白1(FBLN1)水平与腹主动脉钙化(AAC)的相关性。方法 收集74例MHD患者的一般资料和生化指标,根据腹主动脉钙化评分(AACs)将患者分为无和轻度AAC组36例和中重度AAC组38例。比较2组血清CDC-42、β_(2)-MG、FBLN1水平,采用多因素Logistic回归分析探讨MHD患者发生AAC的危险因素。结果 中重度AAC组透析龄、血磷、全段甲状旁腺激素(iPTH)、CDC-42、β_(2)-MG、FBLN1水平高于无和轻度AAC组,差异有统计学意义(P<0.05)。MHD患者AAC与血磷、iPTH、CDC-42、β_(2)-MG、FBLN1、透析龄呈正相关(P<0.05)。高CDC-42、β_(2)-MG、FBLN1水平及长透析龄是MHD患者发生AAC的独立危险因素(P<0.05)。结论 血清CDC-42、β_(2)-MG、FBLN1水平与MHD患者AAC呈正相关,高CDC-42、β_(2)-MG、FBLN1水平及长透析龄是MHD患者发生AAC的独立危险因素。

Objective To investigate the correlations of serum cell division cycle 42(CDC-42),β_(2)-microglobulin(β_(2)-MG) and fibulin 1(FBLN1) levels with abdominal aortic calcification(AAC) in patients with maintenance hemodialysis(MHD).Methods General information and biochemical indicators of 74 MHD patients were collected,and they were divided into no to mild AAC group(n=36) and moderate to severe AAC group(n=38) based on the Abdominal Aortic Calcification Score(AACs).Serum levels of CDC-42,β_(2)-MG and FBLN1 were compared between the two groups,and multivariate Logistic regression analysis was used to explore the risk factors for AAC in MHD patients.Results The dialysis vintage,serum phosphorus,intact parathyroid hormone(iPTH),CDC-42,β_(2)-MG and FBLN1 levels in the moderate to severe AAC group were significantly higher than those in the no to mild AAC group(P<0.05).AAC in MHD patients was positively correlated with serum phosphorus,iPTH,CDC-42,β_(2)-MG,FBLN1,and dialysis vintage(P<0.05).High levels of CDC-42,β_(2)-MG and FBLN1 as well as long dialysis vintage were independent risk factors for AAC in MHD patients(P<0.05).Conclusion Serum CDC-42,β_(2)-MG and FBLN1 levels are positively correlated with AAC in MHD patients.High levels of CDC-42,β_(2)-MG and FBLN1 as well as long dialysis vintage are independent risk factors for AAC in MHD patients.