铁死亡在急性肾损伤中作用及机制的研究进展

Research progress of role and mechanism of ferroptosis in acute kidney injury

铁死亡是一种新型的调节细胞死亡的策略,其发生过程与细胞内的铁代谢、脂质代谢、氨基酸代谢以及多种信号通路有密切联系。铁死亡在急性肾损伤(AKI)的发病机制中起关键作用。铁死亡可能是治疗缺血再灌注损伤、肾毒性药物、横纹肌溶解综合征、脓毒症等多种原因引起的AKI的重要靶点。本文就铁死亡的调控机制及其在AKI中作用的研究进展予以综述。

Ferroptosis is a novel strategy for regulating cell death,and its occurrence is closely related to intracellular iron metabolism,lipid metabolism,amino acid metabolism,and various signaling pathways.Ferroptosis plays a pivotal role in the pathogenesis of acute kidney injury(AKI).Ferroptosis may serve as an important target for the treatment of AKI caused by various reasons such as ischemia-reperfusion injury,nephrotoxic drugs,rhabdomyolysis syndrome,sepsis,and so on.This paper reviewed the regulatory mechanisms of ferroptosis and its research progress in AKI.