基于数据挖掘分析中医药治疗自身免疫性肝病组方用药规律

Exploration of Prescription and Medication Rules of Chinese Medicine Treating Autoimmune Liver Disease Based on Data Mining

目的:基于数据挖掘分析中医药治疗自身免疫性肝病的组方用药规律及特点。方法:检索中国知网、万方数据库、维普数据库中的文献,依照纳排标准对相关文献进行筛选整理,将处方信息录入中医传承辅助系统V3.0建立数据库,使用“统计分析、方剂分析、关联规则、聚类分析”等模块进行数据挖掘与分析。结果:共纳入符合要求的文献139篇,处方139首,涉及251味中药。药物出现频次前10位依次是柴胡、茵陈、黄芪、赤芍、白术、甘草、茯苓、当归、白芍、郁金;药性以寒性、温性为主;药味以苦味、甘味及辛味为主;归经主入肝经、脾经、肺经;功效前4位依次是补虚类、清热类、利水渗湿类、活血化瘀类。关联规则分析获得18组高频药物组合,排在前4位分别为柴胡-甘草、茯苓-白术、黄芪-白术、茵陈-赤芍。K-means聚类分析挖掘出新核心类方4首。结论:中医药治疗自身免疫性肝病的处方以补虚类、清热类、利水渗湿类、活血化瘀类药物为主,药物组合及类方分析体现出疏肝理气、益气健脾、清热利湿、活血化瘀等治疗方向。

Objective:Based on data mining,to explore the prescription and medication rules and characteristics of Chinese medicine in the treatment of autoimmune liver disease.Methods:The China National Knowledge Infrastructure,Wanfang Database,and VIP Chinese Science and Technology Journal Database were applied for literature retrieval,and the relevant literature was screened and organized according to inclusion and exclusion criteria.Prescription information was entered into the Traditional Chinese Medicine Inheritance Assistance System V3.0 to establish a database.Data mining and analysis were conducted using modules such as"statistical analysis,formula analysis,association rules,and cluster analysis".Results:A total of 139 eligible literature and 139 prescriptions were included,involving 251 Chinese herbal medicines.The top 10 frequency occurrence drugs were Bupleuri Radix,Artemisiae Scopariae Herba,Astragali Radix,Paeoniae Radix Rubra,Atractylodis Macrocephalae Rhizoma,Glycyrrhizae Radix et Rhizoma,Poria,Angelicae Sinensis Radix,Paeoniae Radix Alba,and Curcumae Radix.The medicinal properties were mainly cold and warm,and the medicinal flavour is mainly bitter,sweet,and acrid.The channel entry mainly focused on the liver channel,spleen channel,and lung channel.The top four types of efficacy were supplementing deficiency,clearing heat,promoting urination and percolating dampness,and invigorating blood and dissolving stasis.Association rule analysis obtained 18 high-frequency drug combinations,and the top four were Bupleuri Radix-Glycyrrhizae Radix et Rhizoma,Poria-Atractylodis Macrocephalae Rhizoma,AstragaliRadix-Atractylodis Macrocephalae Rhizoma,and Artemisiae Scopariae Herba-Paeoniae Radix Rubra.K-means clustering analysis identified four new core categorized formulas.Conclusion:The prescriptions of traditional Chinese medicine for treating autoimmune liver disease mainly focuses on supplementing deficiency,clearing heat,promoting urination and percolating dampness,and invigorating blood and dissolving stasis.The medication combination and categorized formula analysis reflect the treatment directions of soothing the liver and rectifying qi,boosting qi and fortifying spleen,clearing heat and draining dampness,and invigorating blood and dissolving stasis.