清胃黄连丸联合西药治疗胃火炽盛型老年慢性牙周炎临床研究

Clinical Study on Qingwei Huanglian Pills Combined with Western Medicine in Treating Senile Chronic Periodontitis with Intense Stomach Fire Syndrome

目的:观察清胃黄连丸联合西药治疗胃火炽盛型老年慢性牙周炎患者的临床疗效。方法:根据随机数字表法将80例胃火炽盛型老年慢性牙周炎患者分为2组各40例。参照组给予罗红霉素胶囊与替硝唑片治疗,联合组给予清胃黄连丸联合罗红霉素胶囊、替硝唑片治疗。2组均连续治疗2周。比较2组治疗前后的中医证候评分、牙周指标(菌斑指数、牙龈指数、探针深度、龈沟出血指数评分)、龈沟液炎症因子[肿瘤坏死因子(TNF-α)、白细胞介素-6(IL-6)、白细胞介素-1β(IL-1β)]水平。比较2组的临床疗效与不良反应发生率。结果:治疗2周后,联合组总有效率高于参照组(P<0.05)。2组牙龈肿痛、渴喜冷饮、口臭、大便干结评分均较治疗前下降(P<0.05),联合组4项中医证候评分均低于参照组(P<0.05)。2组菌斑指数、牙龈指数、探针深度、龈沟出血指数评分均较治疗前下降(P<0.05),联合组4项评分均低于参照组(P<0.05)。2组龈沟液TNF-α、IL-6、IL-1β水平均较治疗前下降(P<0.05),联合组3项指标水平均低于参照组(P<0.05)。2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:采用清胃黄连丸联合西药治疗胃火炽盛型老年慢性牙周炎患者可有效改善牙周炎的症状和体征,减轻炎症,具有良好的治疗效果和安全性。

Objective:To observe the clinical effect of Qingwei Huanglian Pills combined with western medicine in treating senile chronic periodontitis with intense stomach fire syndrome.Methods:A total of 80 elderly patients with chronic periodontitis with intense stomach fire type were divided into two groups according to random number table method,with 40 cases in each group.The reference group was treated with Roxithromycin Capsules and Tinidazole Tablets,and the combination group was given Qingwei Huanglian Pills combined with Roxithromycin Capsules and Tinidazole Tablets.Both groups were treated for two weeks.The traditional Chinese medicine(TCM)syndrome scores,periodontal indexes(scores of plaque indexes,gingival indexes,probe depth and gingival crevicular bleeding indexes)and levels of gingival crevicular fluid inflammatory factors[tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)and interleukin-1β(IL-1β)]before and after treatment were compared between the two groups.The clinical effects and adverse reactions were also compared.Results:After two weeks of treatment,the total effective rate in the combination group was higher than that in the reference group(P<0.05).The scores of TCM syndromes such as gum swelling and pain,thirst for cold drinks,halitosis and dry stool in both groups were decreased when compared with those before treatment(P<0.05),and the above scores in the combination group were lower than those in the reference group(P<0.05).The scores of plaque indexes,gingival indexes,probe depth and gingival crevicular bleeding indexes in the two groups were decreased when compared with those before treatment(P<0.05),and the above scores in the combination group were lower than those in the reference group(P<0.05).The levels of TNF-α、IL-6、IL-1βin gingival creval fluid of the two groups were decreased(P<0.05),and the levels of above indexes in the combination group were lower than those in the reference group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:The therapy of Qingwei Huanglian Pills combined with western medicine can relieve clinical symptoms and signs on elderly patients with chronic periodontitis with intense stomach fire type,decrease adverse reactions,and have curative effects and good safety.