甲泼尼龙琥珀酸钠联合硫酸镁治疗小儿喘息性支气管肺炎的临床疗效及对患者炎症指标的影响

Clinical efficacy of methylprednisolone sodium succinate combined with magnesium sulfate in the treatment of asthmatic bronchopneumonia in children and its influence on inflammatory indexes

目的探讨甲泼尼龙琥珀酸钠联合硫酸镁治疗小儿喘息性支气管肺炎的疗效对患者炎症指标的影响。方法选取2021年10月至2022年10月东台市人民医院收治的130例喘息性支气管肺炎患儿作为研究对象,按照随机数字表法分为常规组与观察组,每组65例。常规组给予甲泼尼龙琥珀酸钠治疗,观察组给予甲泼尼龙琥珀酸钠联合硫酸镁治疗,比较两组临床疗效、炎症指标[超敏C-反应蛋白(hypersensitive C-reactive protein,hs-CRP)、中性粒细胞百分比(percentage of neutrophils,NEUT%)、降钙素原(procalcitonin,PCT)]及不良反应发生情况。结果观察组治疗总有效率高于常规组,差异有统计学意义(P<0.05)。观察组咳嗽、气喘、肺啰音、气促症状消失时间及肺部炎症消失时间、住院时间均短于常规组,差异有统计学意义(P<0.05)。治疗后,两组hs-CRP、NEUT%及PCT均低于治疗前,且观察组低于常规组,差异有统计学意义(P<0.05)。两组不良反应发生率比较差异无统计学意义。结论甲泼尼龙琥珀酸钠联合硫酸镁治疗喘息性支气管肺炎患儿疗效显著,可缩短症状改善时间,改善炎症反应程度,值得临床推广应用。

Objective To analyze the clinical efficacy of methylprednisolone sodium succinate combined with magnesium sulfate in the treatment of asthmatic bronchopneumonia in children and its influence on inflammatory indexes.Methods 130 children with asthmatic bronchopneumo-nia in Dongtai People's Hospital from October 2021 to October 2022 were selected as the research subjects,and they were divided into the routine group and the observation group according to random number table method,with 65 cases in each group.The routine group was given methylprednis-olone sodium succinate,and the observation group was given methylprednisolone sodium succinate combined with magnesium sulfate,the clinical ef-ficacy,inflammatory indexes(high sensitivity C-reactive protein[hs-CRP],percentage of neutrophils[NEUT%]and procalcitonin[PCT])and the occurrence of adverse reactions were compared between the two groups.Results The total effective rate in the observation group was higher than that in the routine group,and the difference was statistically significant(P<0.05).The disappearance time of cough,wheezing,lung rales and short-ness of breath,the disappearance time of pulmonary inflammation and the hospitalization time in the observation group was lower than those in the routine group,and the differences were statistically significant(P<0.05).After treatment,the levels of hs-CRP,NEUT%and PCT of the two groups were lower than those before treatment,and the observation group were lower than those in the routine group,and the differences were sta-tistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups.Conclusion The combination treatment of methylprednisolone sodium succinate and magnesium sulfate in children with wheezing bronchopneumonia can achieve ideal efficacy.