升降散及其中药组成治疗特发性肺纤维化机制的探讨

Mechanism of Shengjiang Powder(升降散) in Treatment of Idiopathic Pulmonary Fibrosis with Traditional Chinese and Western Medicine

特发性肺纤维化(idiopathic pulmonary fibrosis, IPF)是一个发病原因不明的慢性进行性纤维化间质性肺炎,患者预后差,病死率高,目前治疗IPF的药物有吡非尼酮和尼达尼布,但治疗效果稍差,不能彻底治愈患者。升降散升清降浊、调畅气机、活血化瘀、化痰散结、清热解毒,正对IPF痰、瘀、毒互结与肺的病机关键,另外,结合目前对升降散的单药和组方的药理作用研究发现,都可以通过多通路、多靶点减轻或者改善肺纤维化。该文探讨升降散治疗IPF临床应用特点和药理机制,为IPF患者提供新的治疗思路。

Idiopathic pulmonary fibrosis(IPF)is a chronic progressive interstitial pneumonia with unknown etiology.The prognosis of patients is poor,and the mortality rate is high.At present,only pirfenidone and nidanib are used to treat IPF,but the treatment effect is slightly poor,and the patients cannot be completely cured.Shengjiang Powder(升降散)has the functions of clearing away turbidity,regulating Qi-flowing,promoting blood circulation and removing blood stasis,resolving phlegm and resolving stagnation,and clearing away heat and toxic materials,which are the key to the pathogenesis of IPF,including phlegm,blood stasis,toxin and lung.In addition,combined with the pharmacological effects of Shengjiang Powder at present,it is found that IPF can be alleviated or improved through multiple channels and multiple targets.This paper discussed the clinical application characteristics and pharmacological mechanism of Shengjiang Pwder in the treatment of IPF,and provided new treatment ideas for IPF patients.