温脾消痈散结汤治疗间质性肺疾病脾肾虚冷,瘀毒化痈证

Clinical efficacy of Wenpi Xiaoyong Sanjie Tang in the treatment of interstitial lung disease with the syndrome of stasis-toxin transforming into carbuncles due to deficient cold in the spleen and kidney

目的观察温脾消痈散结汤治疗间质性肺疾病脾肾虚冷,瘀毒化痈证的临床疗效。方法选择长春中医药大学附属医院疗区就诊的72例间质性肺疾病患者,随机分为治疗组和对照组,各36例。治疗组口服温脾消痈散结汤;对照组口服乙酰半胱氨酸泡腾片,每次600 mg,每日3次。4周后,观察患者临床疗效、症状积分、呼吸困难评分、全肺CT评分,肺功能6 min步行距离。结果治疗组总有效率91.67%,优于对照组总有效率58.33%(P<0.05);2组治疗后主要症状积分、呼吸困难CAT评分、全肺CT评分,肺功能6 min步行距离均较治疗前好转(P<0.05),且治疗组优于对照组(P<0.05)。结论温脾消痈散结汤可用于温脾助阳、消痈散结,有效降低间质性肺疾病病死率、延缓病情进展,提高患者生活质量。

Objective To observe the clinical efficacy of Wenpi Xiaoyong Sanjie Tang in the treatment of interstitial lung disease with the syndrome of stasis-toxin transforming into carbuncles due to deficient cold in the spleen and kidney.Methods A total of 72 patients with interstitial lung disease who visited the Affiliated Hospital of Changchun University of Chinese Medicine were randomly divided into a treatment group and a control group,with 36 patients in each group.The treatment group took Wenpi Xiaoyong Sanjie Tang orally,while the control group took orally acetylcysteine effervescent tablets,600 mg each time,three times a day.After 4 weeks,the patients'symptoms,lung function,whole lung CT scores,6-minute walking distance,and respiratory distress CAT scores were observed in both groups.Results The total effective rate was 91.67%in the treatment group,which was better than that in the control group(58.33%,P<0.05).After treatment,both groups showed an improvement in the lung function scores,whole lung CT scores,6-minute walking distance,and respiratory distress CAT scores compared to before treatment(P<0.05),and the treatment group was superior to the control group(P<0.05).Conclusion Wenpi Xiaoyong Sanjie Tang has a significant therapeutic effect in the treatment of interstitial lung disease and is worthy of promotion.