补阳还五汤预防胃癌患者化疗后相关周围神经毒性临床研究

Clinical study on Buyang Huanwu Tang in preventing XELOX chemotherapy-induced peripheral neurotoxicity in gastric cancer patients

目的研究补阳还五汤预防胃癌患者奥沙利铂联合卡培他滨(XELOX)化疗后相关周围神经毒性的价值。方法选取徐州市中心医院2021年1月—2023年1月收治的80例胃癌患者,按照随机数表法分为观察组和对照组,各40例。对照组单纯采用奥沙利铂联合卡培他滨化疗,观察组于化疗后服用补阳还五汤,直至下一个疗程化疗开始。比较2组患者治疗效果及治疗前后血清肿瘤标志物水平、神经传导速度、中医证候积分、不良反应、周围神经毒性分级等情况。结果治疗后2组患者运动神经传导速度(MNCV)、感觉神经传导速度(SNCV)下降(P<0.05),观察组MNCV、SNCV高于对照组,差异有统计学意义(P<0.05);治疗后2组患者中医证候积分血清肿瘤标志物、神经传导速度均较治疗前降低(P<0.05),且观察组优于对照组(P<0.05);观察组治疗后患者干预后周围神经毒性分级优于对照组(P<0.05)。结论补阳还五汤对于预防胃癌患者化疗后周围神经毒性方面安全有效,能够改善化疗后患者的周围神经毒性的症状,提高患者生活质量。

Objective To study the value of Buyang Huanwu Tang in preventing peripheral neurotoxicity in gastric cancer patients after chemotherapy with oxaliplatin combined with capecitabine(XELOX).Methods A total of 80 gastric cancer patients admitted to our hospital from January 2021 to January 2023 were enrolled in the study.They were randomly divided into an observation group and a control group,with 40 patients in each group.The control group was treated with XELOX chemotherapy alone,while the observation group was treated with Buyang Huanwu Tang on the basis of XELOX chemotherapy until the start of the next course of chemotherapy.The therapeutic effects of the two groups were compared,and the levels of serum tumor markers,nerve conduction velocity,traditional Chinese medicine syndrome scores,adverse reactions,and peripheral neurotoxicity gradings were compared before and after treatment between the two groups.Results After treatment,the motor nerve conduction velocity(MNCV)and sensory nerve conduction velocity(SNCV)were decreased in the two groups(P<0.05),while the MNCV and SNCV were higher in the observation group than those in the control group,with a statistical significance(P<0.05).After treatment,the TCM syndrome scores were significantly decreased in the two groups of patients(P<0.05),and the observation group was lower than the control group(P<0.05).After intervention,the peripheral neurotoxicity grading was lower in the observation group than that in the control group(P<0.05).Conclusion Buyang Huanwu Tang is safe and effective in preventing peripheral neurotoxicity in gastric cancer patients after XELOX chemotherapy,which can improve the symptoms of peripheral neurotoxicity in them and improve their quality of life.