消化道肿瘤患者术后营养支持与快速康复的临床观察

Clinical observation of postoperative nutritional support and rapid rehabilitation in patients with gastrointestinal tumors

目的分析消化道肿瘤患者术后营养支持与快速康复的关系。方法将2020年11月至2023年11月重庆市大足区人民医院胃肠肿瘤患者460例作为研究对象,按照随机数字表法为观察组(n=230)和对照组(n=230),观察组实施针对性肠内营养,对照组则实施肠外营养,比较两组患者的临床疗效、营养状况和免疫功能相关指标。结果观察组患者临床总有效率为97.33%,对照组为87.4%,两组差异有统计学意义(P<0.05);两组治疗前总白蛋白、清蛋白、转铁蛋白以及前清蛋白差异无统计学意义(P>0.05);治疗后,观察组总白蛋白、清蛋白、转铁蛋白以及前清蛋白均高于对照组,差异有统计学意义(P<0.05);观察组术后CD4和CD4/CD8较术前上升(P<0.05),对照组CD4和CD4/CD8较术前下降(P<0.05)。两组患者手术前后IgA和IgG差异有统计学意义(P<0.05)。结论消化道肿瘤患者应用针对性肠内营养有利于促进患者的治疗效果,有助于改善患者的营养状况,且在一定程度上提高了患者的免疫功能,促进患者快速康复。

Objective To analyze the relationship between postoperative nutritional support and rapid rehabilitation in patients with gastrointestinal tumors.Methods A total of 460 patients with gastrointestinal tumor in Dazu District People's Hospital of Chongqing from November 2020 to November 2023 were selected as the study subjects.According to random number table method,the observation group(n=230)and the control group(n=230)were divided into two groups.The observation group received targeted enteral nutrition,while the control group received parenteral nutrition.The clinical efficacy,nutritional status and immune function related indexes of the two groups were compared.Results The total effective rate was 97.33%in the observation group and 87.4%in the control group,the difference between the two groups was statistically significant(P<0.05).There was no significant difference in total albumin,albumin,transferrin and prealbumin between the two groups before treatment(P>0.05).After treatment,the total albumin,albumin,transferrin and prealbumin in observation group were higher than those in control group,with statistical significance(P<0.05).CD4 and CD4/CD8 in the observation group increased after surgery(P<0.05),while CD4 and CD4/CD8 in the control group decreased after surgery(P<0.05).There were significant differences in IgA and IgG between the two groups before and after operation(P<0.05).Conclusion The application of targeted enteral nutrition in patients with gastrointestinal tumors can promote the therapeutic effect of patients,help to improve the nutritional status of patients,and improve the immune function of patients to a certain extent,and promote the rapid recovery of patients.