原发性肝癌与中医体质相关性的Meta分析

Correlation Between Primary Liver Cancer and Traditional Chinese Medicine Constitution:A Meta-analysis

目的系统评价原发性肝癌患者中医9种体质分布情况,初步明确该病常见的高危体质类型,为中医药防治原发性肝癌提供循证医学证据。方法检索知网、万方、维普、PubMed、Web of science建库至2024年7月1日所有评价原发性肝癌与中医体质类型相关性的临床研究文献,以系统评价方法对检索文献进行筛选、质量评价及资料整合,对最终纳入的文献采用Stata17软件进行荟萃分析。结果共纳入8项研究的1370例患者,Meta分析提示原发性肝癌患者各中医体质类型的比例及95%置信区间依次为平和质21.3%(15.5%~27.8%)、瘀血质14.9%(7.6%~24%)、阳虚质14.2%(7.9%~22%)、气虚质13.7%(9.1%~19%)、湿热质12.7%(9.2%~16.6%)、痰湿质7.5%(4.3%~11.4%)、气郁质5.2%(3.2%~7.6%)、阴虚质4.8%(1.6%~9.3%)、特禀质2%(0.7%~3.9%)。结论瘀血质、阳虚质、气虚质、湿热质是原发性肝癌患者的主要体质类型,可能是原发性肝癌发生的高危因素。

Objective To systematically evaluate the distribution of 9 traditional Chinese medicine(TCM)constitution types in primary liver cancer patients,and to preliminarily identify common high-risk constitution types of primary liver cancer,providing evidence for the prevention and treatment of primary liver cancer with TCM.Methods Clinical research literature on the correlation between primary liver cancer and TCM constitution types was searched in databases including CNKI,Wanfang,VIP,PubMed,and Web of Science from database establishment to July 1,2024.Systematic review methods were used for screening,quality evaluation,and data integration.Meta-analysis was performed on the included studies using Stata 17 software.Results A total of 8 studies involving 1370 patients were included.The Meta-analysis indicated that the proportion and 95%confidence interval of various TCM constitution types in primary liver cancer patients were as follows:balanced constitution was 21.3%(15.5%~27.8%),blood stasis constitution was 14.9%(7.6%~24%),yang deficiency constitution was 14.2%(7.9%~22%),qi deficiency constitution was 13.7%(9.1%~19%),damp-heat constitution was 12.7%(9.2%~16.6%),phlegm-damp constitution was 7.5%(4.3%~11.4%),qi stagnation constitution was 5.2%(3.2%~7.6%),yin deficiency constitution was 4.8%(1.6%~9.3%),and special constitution was 2%(0.7%~3.9%).Conclusion Blood stasis constitution,yang deficiency constitution,qi deficiency constitution,and damp-heat constitution are the primary types of primary liver cancer patients,and may be the high risk factors for the occurrence of primary liver cancer.