定量测量胰腺CT值预测2型糖尿病发生率及其相关因素的研究

Quantitative Measurement of Pancreatic CT Values in Predicting the Incidence of Type 2 Diabetes Mellitus and Related Factors

目的探讨定量测量胰腺CT值预测2型糖尿病发生率的方法,并探讨2型糖尿病组与血糖正常组生化指标中的甘油三脂(TG)、总胆固醇(TC)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)的差异性。方法回顾性分析233例病例,其中2型糖尿病组114例,正常组119例。对233例患者的胰腺CT值与空腹血糖做相关性分析,以空腹血糖7.0mmol/L作为截断值,绘制ROC曲线评价诊断效能,并对2型糖尿病组与正常组做独立样本t检验,分析2型糖尿病组与正常组的胰腺CT值、甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)的差异性。结果胰腺CT值与空腹血糖的相关系数为-0.465(P<0.001),以空腹血糖7.0mmol/L作为截断值时,ROC曲线分析预测血糖异常的CT临界值为39HU,AUC为0.839,敏感性为70.2%,特异性为84.0%,约登指数为0.542。2型糖尿病组与正常组中的胰腺CT值、甘油三酯(TG)具有显著差异(P<0.05),总胆固醇(TC)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)无显著差异(P>0.05)。结论胰腺CT值反映了胰腺脂肪浸润程度,它与甘油三酯(TG)呈正相关,胰腺CT值的定量测量可用于预测2型糖尿病的发生。

Objective To investigate the incidence of type 2 diabetes mellitus(T2DM) predicted by quantitative measurement of pancreatic CT value,and to explore the differences of biochemical indexes including triglyceride(TG),total cholesterol(TC),high-density lipoprotein(HDL) and low-density lipoprotein(LDL) between T2DM group and normal blood glucose group Methods A total of 233 patients were retrospectively analyzed and the CT value of pancreas was measured,including 114 patients in type 2diabetes group and 119 patients in normal group.The correlation between the CT value of pancreas and fasting blood glucose was analyzed.The cut-off value of fasting blood glucose was 7.0mmol/L,and the ROC curve was drawn to evaluate the diagnostic efficiency.Independent sample t test was performed to analyze the difference of pancreatic CT value,triglyceride(TG),total cholesterol(TC),high density lipoprotein(HDL) and low density lipoprotein(LDL) between type 2 diabetes group and normal group.Results The correlation coefficient between pancreatic CT value and fasting blood glucose was-0.465(P<0.001).When fasting blood glucose was 7.0mmol/L as the cut-off value,the cut-off value of ROC curve analysis for predicting abnormal blood glucose was 39HU,AUC was 0.839,sensitivity was 70.2%,specificity was 84.0%,and Youden index was 0.542.There were significant differences in pancreatic CT value and triglyceride(TG) between T2DM group and normal group(P<0.05),but no significant differences in total cholesterol(TC),high density lipoprotein(HDL) and low density lipoprotein(LDL)(P>0.05).Conclusion Pancreatic CT value reflects the degree of pancreatic fatty infiltration,which is positively correlated with triglyceride(TG).The quantitative measurement of pancreatic CT value can be used to predict the occurrence of type 2 diabetes mellitus.