脂噬在糖尿病肾病中作用机制的研究进展

Advances in the mechanism of lipophagy in diabetic nephropathy

糖尿病肾病(DN)是糖尿病患者进展为终末期肾脏病的主要原因,其中脂质代谢紊乱及肾脏脂质异位沉积是DN发病及进展的关键病理因素之一。脂噬是一种新发现的选择性自噬形式,通过溶酶体介导选择性降解细胞内储存中性脂质的细胞器脂滴,从而减轻脂质异位沉积,维持能量代谢稳态。现有证据表明,脂噬激活可以减轻DN状态下脂毒性和肾损伤,成为DN研究的新靶点。文章主要从脂噬途径、主要调控因子及其在DN中作用机制的研究进展进行综述。

Diabetic nephropathy(DN)is a major cause of the progression to end-stage renal disease in patients with diabetes mellitus.Lipid metabolic disorder and ectopic deposition of renal lipids are the key pathological factors of diabetic nephropathy and progression of DN.Lipophagy is a newly discovered form of selective autophagy that degrades lipid droplets stored in cells through lyso-somal-mediated degradation,thereby alleviating lipid deposition and maintaining energy metabolism homeostasis.Existing evidence suggests that the activation of lipophagy can reduce lipotoxicity and renal injury in DN,making it a new target for DN research.This ar-ticle mainly reviews the progress of lipophagy pathway,main regulatory factors and its mechanism in DN.