Rational management of the plant microbiome for the Second Green Revolution

The Green Revolution of the mid-20th century transformed agriculture worldwide and has resulted in envi-ronmental challenges.A new approach,the Second Green Revolution,seeks to enhance agricultural pro-ductivity while minimizing negative environmental impacts.Plant microbiomes play critical roles in plant growth and stress responses,and understanding plant–microbiome interactions is essential for developing sustainable agricultural practices that meet food security and safety challenges,which are among the United Nations Sustainable Development Goals.This review provides a comprehensive exploration of key deterministic processes crucial for developing microbiome management strategies,including the host effect,the facilitator effect,and microbe–microbe interactions.A hierarchical framework for plant mi-crobiome modulation is proposed to bridge the gap between basic research and agricultural applications.This framework emphasizes three levels of modulation:single-strain,synthetic community,and in situ mi-crobiome modulation.Overall,rational management of plant microbiomes has wide-ranging applications in agriculture and can potentially be a core technology for the Second Green Revolution.