Immune Regulatory Networks and Therapy of yδT Cells in Liver Cancer:Recent Trends and Advancements

The roles of γδ T cells in liver cancer,especially in the poten-tial function of immunotherapy due to their direct cytotoxic effects on tumor cells and secretion of important cytokines and chemokines,have aroused research interest.This re-view briefly describes the basic characteristics of γδ T cells,focusing on their diverse effects on liver cancer.In particular,different subtypes of γδ T cells have diverse or even opposite effects on liver cancer.We provide a detailed description of the immune regulatory network of γδ T cells in liver can-cer from two aspects:immune components and nonimmune components.The interactions between various components in this immune regulatory network are dynamic and pluralis-tic,ultimately determining the biological effects of γδ T cells in liver cancer.We also integrate the current knowledge of γδ T-cell immunotherapy for liver cancer treatment,emphasiz-ing the potential of these cells in liver cancer immunotherapy.