Update on the STING Signaling Pathway in Developing Nonalcoholic Fatty Liver Disease

Nonalcoholic fatty liver disease(NAFLD)is a prevalent chronic liver condition with limited treatment options.Inflammation caused by metabolic disturbances plays a significant role in NAFLD development.Stimulator of interferon gene(STING),a critical regulator of innate immunity,induces the production of interferons and other pro-inflammatory factors by recognizing cytoplasmic DNA to defend against pathogen infection.The STING-mediated signaling pathway appears to play a vital role in hepatic inflammation,metabolic disorders,and even carcinogenesis.Promisingly,pharmacological interventions targeting STING have shown improvements in the pathological state of NAFLD.Macrophages,dendritic cells,natural killer cells,and T cell pathways regulated by STING present potential novel druggable targets for NAFLD treatment.Further research and development in this area may offer new therapeutic options for managing NAFLD effectively.