影响拟输血肿瘤患者血小板抗体阳性的相关因素Logistic回归分析

Logistic regression analysis of related factors affecting positive platelet antibody in tumor patients with necessity for blood transfusion

目的分析影响拟输血肿瘤患者血小板抗体阳性的相关因素。方法收集2021年2月至2023年3月于三门峡市第三人民医院及黄河三门峡医院肿瘤内科可能需反复输注血小板的94例肿瘤患者的性别、年龄、输血史、肿瘤类型、生育史、输血次数等临床资料,采用SPSS 19.0统计软件对简化敏化红细胞血小板血清学试验筛查肿瘤患者血小板抗体结果进行分析处理,并评估这些指标对血小板输注的影响和其相关性。结果在94例肿瘤患者中,有30例患者血小板抗体阳性,阳性率为31.91%,比较不同血小板抗体阳性强度患者血小板输注无效率,其差异无统计学意义(P>0.05);其中,女性(43.48%)、有输血史(43.75%)、血液肿瘤(45.76%)、有生育史(40.00%)、输血次数多(63.64%)的患者血小板抗体阳性率高,差异有统计学意义(P<0.05),比较不同年龄患者血小板抗体阳性率,其差异无统计学意义(P>0.05);logistic回归分析显示,影响血小板抗体阳性的独立危险因素为输血史、血液肿瘤、生育史、输血次数(P<0.05)。结论有输血史、血肿瘤史、生育史及输血次数多的患者血小板抗体阳性率较高。对于此类患者,应在输血小板前进行血小板抗体筛查,并选择合适的血小板输注,以提高血小板输注的疗效,保证输血的安全性和有效性。

Objective To analyze the related factors influencing positive platelet antibody in tumor patients with necessity for blood transfusion.Methods Clinical data such as gender,age,blood transfusion history,tumor type,fertility history,and transfusion frequency were collected from 94 tumor patients who may need repeated platelet transfusion from February 2021 to March 2023 in oncology department of the third people's hospital of Sanmenxia and Yellow River Sanmenxia Hospital.SPSS 19.0 statistical software was used to analyze the results of screening platelet antibodies in tumor patients by simplified sensitized erythrocyte platelet serology assay.The influence and correlation of these indicators on platelet transfusion were evaluated.Results Among the 94 tumor patients,30 patients were positive for platelet antibody,with a positive rate of 31.91%.There was no significant difference in platelet transfusion inefficiency in patients with different platelet antibody positive intensity(P>0.05).Univariate analysis showed that the positive rate of platelet antibody was higher in women(43.48%),patients with blood transfusion history(43.75%),blood tumor(45.76%),fertility history(40.00%)and more transfusion times(63.64%),the difference was statistically significant(P<0.05),and there was no statistically significant difference in the positive rate of platelet antibody among patients of different ages(P>0.05).Logistic regression analysis showed that blood transfusion history,hematologic neoplasms,childbearing history and times of blood transfusion were main independent risk factors of positive platelet antibody(P<0.05).Conclusion Patients with blood transfusion history,blood tumor history,fertility history and more blood transfusion times have a higher platelet antibody positive rate.Before platelet transfusion,platelet antibody screening should be performed for these patients to select a compatible platelet transfusion,so as to improve the efficacy of platelet transfusion and ensure the safety and effectiveness of transfusion.