气滞胃痛颗粒现代研究进展

Modern Research on Qizhi Weitong Granules:A Review

气滞胃痛颗粒是由柴胡、白芍、枳壳、香附(炙)、延胡索(炙)、甘草(炙)6味药材组成的成方制剂,具有疏肝理气、和胃止痛的功效,用于肝郁气滞、胸痞胀满、胃脘疼痛等。经多年临床实践,已成为临床治疗胃脘痛一线用药。目前,研究者们已开展了气滞胃痛颗粒及其处方药味的提取纯化工艺优化、化学成分鉴定、入血成分表征、质量控制方法建立、消化系统疾病药效验证、作用机制探索、临床疗效观察等研究工作,取得了一系列的成果。该文旨在总结近年来气滞胃痛颗粒相关研究成果,从药效物质、质量控制、药理药效、作用机制、临床疗效5个方面进行系统论述,以期为气滞胃痛颗粒进一步深入研究及现代化发展提供思路。

Qizhi Weitong granules composed of Bupleuri Radix,Paeoniae Radix Alba,Aurantii Fructus,Cyperi Rhizoma(processed),Corydalis Rhizoma(processed),and Glycyrrhizae Radix et Rhizoma have the effects of soothing the liver,regulating Qi movement,and harmonizing the stomach to relieve pain.This preparation is thus used for the treatment of liver depression,Qi stagnation,chest distension,and epigastric pain.It has become a first-line medication for the treatment of epigastric pain after years of clinical practice.At present,researchers have carried out extensive studies on Qizhi Weitong granules,including the optimization of the extraction and purification process,identification of chemical components,characterization of absorbed components,establishment of quality control methods,validation of pharmacological effect on digestive system diseases,exploration of the mechanism,and observation of clinical efficacy.The studies have achieved fruitful results.This article summarizes the research achievements related to Qizhi Weitong granules in recent years from pharmacological substances,quality control,pharmacological effect,mechanism of action,and clinical efficacy,aiming to provide ideas for in-depth research and modern development of Qizhi Weitong granules.