金属有机骨架在皮肤递药系统中的研究进展

Research Advances in Metal-Organic Frameworks for Dermal Delivery Systems

金属有机骨架(MOFs)具有比表面积大、孔隙率高、载药量多、缓释效果好、生物相容性强等特性,是生物医学领域最受欢迎的功能性材料之一,已被广泛应用于各类疾病的预防和治疗,应用前景十分广阔。皮肤递药作为一种避免肝脏首过效应的给药途径,具有副作用小、药效持久等特点,逐渐成为科研人员的研究重点。近年来,研究者将MOFs应用于皮肤递药领域,凭借其自身的优良特性为皮肤递药制剂提供了新的思路。本文主要介绍近10年MOFs在皮肤递药方面的应用,总结了MOFs作为皮肤制剂药物载体或活性成分的研究进展,为后续研究人员提供参考。

Metal-organic frameworks(MOFs),known as porous coordination polymers,refer to metal ions or metal clusters and organic ligands through the self-assembly process,the formation of periodic infinite network structure of the new crystalline porous materials,with high specific surface area,high porosity,high drug loading,good sustained release effect,good biocompatibility.MOFs have emerged as one of the most sought-after functional materials in the biomedical field.They have found extensive applications in disease prevention and treatment,showcasing immense potential for future advancements.Cutaneous drug delivery has gained increasing attention due to its ability to bypass the liver first-pass effect while offering minimal side effects and long-lasting efficacy.In recent years,MOFs have been applied to the field of skin drug delivery,providing new ideas for skin drug delivery preparations with their own excellent characteristics.This paper reviews the literatures of MOFs in dermal delivery applications in the past 10 years,summarizes the research progress of MOFs as transdermal drug carriers or active ingredients,and provides reference for subsequent researchers.