颅脑创伤后应激性高血糖的研究进展

Research progress of stress-induced hyperglycemia in traumatic brain injury

颅脑创伤(traumatic brain injury,TBI)是一种常见的中枢神经系统损伤,也是全球成人和儿童死亡和致残的重要原因之一。TBI后常伴随应激性高血糖(stress-induced hyperglycemia,SIH)的出现,可能是由急性损伤或其他应激因素引起的血糖水平暂时性升高。TBI后SIH的发生与TBI患者的死亡与预后密切相关。本文综述了SIH在TBI背景下的定义、发生机制以及对机体的影响,并探讨了胰岛素和其他治疗在TBI患者中的应用现状及未来研究方向。

As a prevalent central nervous system damage disease,traumatic brain injury(TBI)stands as a significant cause of mortality and disability among adults and children worldwide.TBI is often accompanied by stress-induced hyperglycemia(SIH),characterized by a temporary elevation of blood glucose levels caused by acute injury or other stress factors.The occurrence of SIH following TBI is closely associated with the mortality and prognosis of TBI patients.This review synthesizes the current understanding of SIH within the context of TBI,including its definition,mechanisms of occurrence,and impact on the body.Additionally,it discusses the current state of insulin and other treatment in TBI patients and explores potential research directions.