肠易激综合征患者局部自发性脑活动改变的元分析

Meta-analysis of local spontaneous brain activity changes in patients with irritable bowel syndrome

目的:通过静息态功能磁共振成像(rs-fMRI)研究肠易激综合征(IBS)患者的脑活动异常区域,揭示IBS患者潜在的大脑神经机制。方法:检索2023年3月以前采用低频波动幅度(ALFF)、分数低频波动振幅(fALFF)和局部一致性(ReHo)方法探讨IBS患者静息态大脑异常激活改变的文献。汇总既往研究中IBS患者相对于健康志愿者局部自发脑活动异常的脑区,采用标记差异映像(SDM)软件进行数据分析。结果:共纳入16篇文献,包括461例IBS和416例健康对照。基于元分析证实IBS患者左脑舌回、左脑楔叶、右侧岛脑、右脑枕中回、右侧丘脑的局部自发脑活动明显升高;右侧回直肌、右侧额中回、右侧缘上回的局部自发脑活动明显降低(P<0.001,峰高Z>1,簇范围≥20个体素)。结论:应用元分析证实了IBS患者相关核心脑功能异常的脑区,这些发现有助于划定特定感兴趣区和理解IBS的神经生物学基础。

Objective:To explore the areas of abnormal brain activity in patients with irritable bowel syndrome(IBS)using resting state functional magnetic resonance imaging(rs-fMRI),revealing underlying neural mechanisms in patients with IBS.Methods:The literature before March 2023 were searched,which discussed the abnormal brain activity changes on resting state in patients with IBS using amplitude of low-frequency fluctuation(ALFF),fraction amplitude of low-frequency fluctuation(fALFF)and regional homogeneity(ReHo)methods.The brain regions with abnormal local spontaneous brain activity in IBS patients compared with healthy volunteers in previous studies were summarized,and the data were analyzed by signed differential mapping(SDM)software.Results:A total of 16 studies were included(461 cases of IBS and 416 healthy controls).Based on the meta-analysis,the local spontaneous brain activity of left lingual gyrus,left cuneus,right insular,right middle occipital gyrus and right thalamus significantly increased in IBS patients.However,the local spontaneous brain activity significantly decreased in the right ilerectus muscle,right middle frontal gyrus and right superior marginal gyrus(P<0.001,peak height Z>1,cluster range≥20 voxel).Conclusion:A meta-analysis was used to identify brain regions with associated abnormal core brain function in IBS patients.These findings help delineate specific areas of interest and understand the neurobiological basis of IBS.