催化剂ZIF-67的制备及合成D-阿洛酮糖的工艺优化

Preparation of Catalyst ZIF-67 and Optimize on the Synthesis of D-Allulose

为降低D-阿洛酮糖的生产成本,本研究旨在开发一款易回收、可重复使用的D-阿洛酮糖无机催化剂,并优化该催化剂生产D-阿洛酮糖的工艺。本文利用Co^(2+)和2-甲基咪唑在水相中合成沸石咪唑酯骨架材料(Zeolitic imidazolate framework-67,ZIF-67),并对其进行表征;并以pH(A)、催化温度(B)、催化时间(C)展开单因素实验;进一步采用响应面法对其催化工艺进行优化。ZIF-67呈现菱形十二面体的结构,催化性能良好,Design Expert 13预测最优反应条件为pH11.1、温度80.0℃、催化时间11.2 min。此条件下,ZIF-67催化活性为1003.5μmol·min^(-1)·g^(-1)。本文首次开发一款D-阿洛酮糖无机催化剂ZIF-67,并通过响应曲面较好地预测出ZIF-67合成D-阿洛酮糖的最佳反应条件,也为D-阿洛酮糖工业化生产开辟了新途径。

To reduce the manufacturing cost of D-allulose,a recyclable and reusable inorganic catalyst was developed for D-allulose production,and process using this catalyst to produce D-allulose also was optimized in this article.Zeolitic imidazolate framework-67(ZIF-67)was synthesized using Co2+and 2-methylimidazole in aqueous phase.Then the structure of ZIF-67 was characterized.The single factor test was carried out to select suitable value of pH(A),catalytic temperature(B)and reaction time(C).Based on the results of single factor experiments,the catalytic process was optimized using response surface methodology.The results showed that ZIF-67 had a rhombic dodecahedral structure and exhibited excellent catalytic performance.The Design Expert 13 software predicted the optimal reaction condition was pH11.1,80.0℃and 11.2 min.Under these conditions,the catalytic activity of ZIF-67 was 1003.5µmol·min^(-1)·g^(-1).A D-allulose inorganic catalyst was developed and the optimal reaction condition was carried out using response surface methodology in this paper.It also opens up a new path for the industrial production of D-allulose.