ADGRV1多态性与子宫颈癌关联性研究

Study on the association between ADGRV1 polymorphism and cervical cancer

目的探讨粘附G蛋白偶联受体V1(ADGRV1)基因多态性与子宫颈癌易感性之间是否存在关联性。方法采取病例对照(1∶1)匹配研究法,分析ADGRV1基因多态性与子宫颈癌易感性是否有关,同时对子宫颈癌患者ADGRV1基因的rs59661306位点基因分布在不同病理特征间作对比。结果ADGRV1基因的rs59661306位点携带GA及GG基因型的个体比携带AA基因型的个体患子宫颈癌的风险显著增大,相应的OR(95%CI)为4.20(1.64~10.72)和3.22(1.23~8.38)。ADGRV1基因的rs59661306位点基因分布在高危人乳头瘤病毒(HPV)感染、肿瘤家族史者、鳞状细胞癌抗原(SCC)不同值中的差异有统计学意义(P<0.05),在淋巴结转移、病理类型、临床分期等临床病理特征中差异无统计学意义。在ADGRV1基因的rs59661306位点携带GA及GG基因型比携带AA基因型的个体更易伴高危HPV感染,相应的OR(95%CI)为13.70(2.32~80.80)和17.53(2.76~111.30)。携带AA基因型的子宫颈癌个体不易伴有家族性肿瘤史。结论ADGRV1基因的rs59661306位点基因多态性与子宫颈癌发病风险有一定相关性,在部分高危环境因素中促使子宫颈癌发生。

Objective To explore the relationship between genetic polymorphisms of ADGRV1 rs59661306 and susceptibility to cervical cancer.Method A case-control(1∶1)matching study was conducted to analyze whether the ADGRV1 gene polymorphism is related to susceptibility to cervical cancer,and to compare the distribution of the rs59661306 locus of the ADGRV1 gene in cervical cancer patients with different pathological characteristics.Results Individuals carrying the GA and GG genotypes at the rs59661306 locus of the ADGRV1 gene had a significantly increased risk of cervical cancer compared to individuals carrying the AA genotype,with corresponding OR(95%CI)values of 4.199(1.644~10.72)and 3.215(1.23~8.377).The rs59661306 locus of the ADGRV1 gene showed significant differences(P<0.05)in the distribution of high-risk HPV infection,family history of tumors,and different values of SCC.There was no correlation between clinical pathological features such as lymph node metastasis,pathological type,and clinical stage.Individuals carrying the GA and GG genotypes at the rs59661306 locus of the ADGRV1 gene are more susceptible to high-risk HPV infection than those carrying the AA genotype,with corresponding OR(95%CI)values of 13.7(2.32~80)and 17.52(2.76~111.3).Individuals with cervical cancer of type AA are less likely to have a family history of tumors.Conclusion The rs59661306 polymorphism of the ADGRV1 gene is associated with the risk of cervical cancer and may contribute to the development of cervical cancer in some high-risk environmental factors.