屈螺酮炔雌醇Ⅱ对子宫内膜息肉术后复发预防疗效分析

Analysis of Curative Effect of Drospirosterone Ethoestradiol II on Postoperative Recurrence Prevention of Endometrial Polyps

目的探析子宫内膜息肉手术患者采取屈螺酮炔雌醇Ⅱ对其术后复发的预防效果。方法选取2021年1月~2022年1月就诊于我院的子宫内膜息肉患者(均予宫腔镜子宫内膜病损切除术治疗)研究,总纳入病例数120例,按照随机数字表法分组,对照组术后不予以药物干预,治疗组术后予屈螺酮炔雌醇Ⅱ,比较指标:治疗效果、子宫内膜厚度/月经失血图(PBAC)、激素水平、复发率等。结果①治疗效果:治疗组有效率,记录数值高于对照组,差异于统计学有意义(P<0.05);②子宫内膜厚度/月经失血图(PBAC):治疗组较对照组,子宫内膜厚度更小,PBAC评分更低,差异于统计学有意义(P<0.05);③激素水平:治疗组较对照组,LH(黄体生成素)、FSH(卵泡刺激素)更低,E2(雌二醇)更高,差异于统计学有意义(P<0.05);④复发率:术后3个月,两组复发率比较(P>0.05),术后6个月、12个月,治疗组较对照组,复发率更低,差异于统计学有意义(P<0.05);⑤生活质量:治疗组较对照组,精神健康、心理/社会功能评分更高,差异于统计学有意义(P<0.05)。结论子宫内膜息肉术后预防性采取屈螺酮炔雌醇Ⅱ可有效防范息肉复发,抑制子宫内膜增生,促进月经量及激素水平恢复,改善生活质量,值得推广。

Objective To explore the preventive effect of drospiroone ethoestradiol II on postoperative recurrence of endometrial polyps in patients undergoing surgery.Methods A total of 120 patients with endometrial polyps admitted to our hospital from January 2021 to January 2022(all of whom were treated with hysteroscopic resection of endometrial lesions)were selected for the study.The total number of included cases was divided into groups according to random number table method.The control group was given no postoperative drug intervention,while the treatment group was given drospiroone eilestradiol II after surgery.Treatment effect,endometrial thickness/menstrual blood loss map(PBAC),hormone levels,recurrence rate,etc.Results①treatment effect:the effective rate of the treatment group was higher than that of the control group,the difference was statistically significant(P<0.05);②endometrial thickness/menstrual blood loss map(PBAC):compared with the control group,the endometrial thickness in the treatment group was smaller and the PBAC score was lower,the difference was statistically significant(P<0.05);③hormone levels:LH(luteinizing hormone)and FSH(follicle-stimulating hormone)were lower in the treatment group than in the control group,and E2(estradiol)was higher,the difference was statistically significant(P<0.05);④recurrence rate:3 months after surgery,the recurrence rate of the two groups was compared(P>0.05),6 months after surgery,12 months,the treatment group was lower than the control group,the difference was statistically significant(P<0.05);⑤quality of life:the scores of mental health and psychological/social function in the treatment group were higher than those in the control group,and the differences were statistically significant(P<0.05).Conclusion Prophylactic treatment of drospiroestradiol II after operation of endometrial polyps can effectively prevent the recurrence of polyps,inhibit endometrial hyperplasia,promote the recovery of menstrual volume and hormone levels,and improve the quality of life.