血清PLT、ALC与弥漫大B细胞淋巴瘤预后的关系研究

A Study of the Relationship between Serum PLT,ALC and the Prognosis of Diffuse Large B-cell Lymphoma

目的分析血小板计数(platelet,PLT)、淋巴细胞绝对值(absolute lymphocyte count,ALC)与弥漫大B细胞淋巴瘤(diffuse large B-cell lymphoma,DLBCL)预后的关系。方法选取本院2020年3月-2023年2月收治的DLBCL患者85例为研究对象(DLBCL组),另选取同期我院健康体检人群70例作为对照组。比较DLBCL组和对照组血清PLT、ALC水平;根据1年随访结果将85例DLBCL患者分为预后良好组和预后不良组,并比较两组临床特征和血清PLT、ALC水平;采用多因素Logistic回归分析影响DLBCL预后的相关因素。结果DLBCL组PLT、ALC水平均低于对照组,差异有统计学意义(P<0.05);85例DLBCL患者1年预后中,预后良好者62例、预后不良者23例,不同预后者性别、年龄比较无明显差异(P>0.05);预后不良组患者临床Ⅲ/Ⅳ期者占比、IPI评分≥2分者占比、PLT水平均高于预后良好组,预后不良组患者ALC水平均低于预后良好组,差异有统计学意义(P<0.05);多因素Logistic回归分析结果显示,临床Ⅲ/Ⅳ期、IPI评分≥2分、PLT水平上升、ALC水平下降均是影响DLBCL预后的危险因素(P<0.05)。结论血清PLT、ALC水平变化与DLBCL患者预后密切,通过检测PLT、ALC水平,能为临床评估DLBCL预后不良提供可靠信息。

Objective To analyse the relationship between platelet count(PLT),Absolute Lymphocyte Count(ALC)and prognosis of diffuse large B-cell lymphoma(DLBCL).Methods Eighty-five cases of DLBCL patients admitted to our hospital from March 2020 to February 2023 were selected as the study subjects(DLBCL group),and another 70 cases of health check-up population in our hospital during the same period were selected as the control group.Serum PLT and ALC levels were compared between the DLBCL group and the control group;85 patients with DLBCL were divided into a good prognosis group and a poor prognosis group based on the results of 1-year follow-up,and the clinical characteristics and serum PLT and ALC levels of the two groups were compared;and multifactorial logistic regression was used to analyse the relevant factors affecting the prognosis of DLBCL.Results The levels of PLT and ALC in the DLBCL group were lower than those in the control group,and the difference was statistically significant(P<0.05);among the 85 DLBCL patients with 1-year prognosis,there were 62 cases of good prognosis and 23 cases of bad prognosis,and there was no significant difference in the comparison of gender and age of those with different prognosis(P>0.05);the percentage of patients in the poor prognosis group with clinical stage Ⅲ/Ⅳ,the percentage of patients with IPI score≥2,and the level of PLT were higher than that of the good prognosis group,and the level of ALC of the patients in the poor prognosis group was lower than that of the good prognosis group,and the difference was statistically significant(P<0.05);the results of multifactorial logistic regression analysis showed that clinical stage Ⅲ/Ⅳ,IPI score≥2,increasing PLT level,and decreasing ALC level were all risk factors affecting the prognosis of DLBCL(P<0.05).Conclusion Changes in serum PLT and ALC levels are closely related to the prognosis of DLBCL patients,and the detection of PLT and ALC levels can provide reliable information for clinical assessment of poor prognosis of DLBCL.