摘要
Proteins play a pivotal role in coordinating the functions of organisms,essentially governing their traits,as the dynamic arrangement of diverse amino acids leads to a multitude of folded configurations within peptide chains.Despite dynamic changes in amino acid composition of an individual protein(referred to as AAP)and great variance in protein expression levels under different conditions,our study,utilizing transcriptomics data from four model organisms uncovers surprising stability in the overall amino acid composition of the total cellular proteins(referred to as AACell).Although this value may vary between different species,we observed no significant differences among distinct strains of the same species.This indicates that organisms enforce system-level constraints to maintain a consistent AACell,even amid fluctuations in AAP and protein expression.Further exploration of this phenomenon promises insights into the intricate mechanisms orchestrating cellular protein expression and adaptation to varying environmental challenges.
基金
This research was funded by the National Key R&D Program of China(2022YFC2106000)
National Natural Science Foundation of China(32300529,32201242,12326611)
Tianjin Synthetic Biotechnology Innovation Capacity Improvement Projects(TSBICIP-PTJS-001,TSBICIP-PTJJ-007)
Major Program of Haihe Laboratory of Synthetic Biology(22HHSWSS00021)
Strategic Priority Research Program of the Chinese Academy of Sciences(XDC0120201)。
