抗Hp四联疗法在糖尿病合并Hp感染患者中的应用效果及对血清炎性因子水平的影响

Application effect of anti-Hp quadruple therapy in patients with diabetes mellitus complicated with Hp infection and its influences on serum inflammatory factors levels

目的分析抗幽门螺杆菌(Hp)四联疗法在糖尿病合并Hp感染患者中的应用效果及对血清炎性因子水平的影响。方法选择2021年4月至2022年5月宝鸡市第二人民医院与宝鸡市中心医院诊治的110例糖尿病合并Hp感染患者作为研究对象,随机将其分为常规组(55例,对症治疗)和观察组(55例,抗Hp四联疗法)。比较两组的治疗效果。结果观察组的治疗总有效率显著高于常规组(P<0.05)。治疗后,观察组的空腹血糖(FPG)、餐后2小时血糖(2 h PG)水平均显著低于常规组(P<0.05)。治疗后,观察组的C-反应蛋白(CRP)、白细胞介素-6(IL-6)、降钙素原(PCT)、白细胞计数(WBC)、胃泌素-17(G-17)、胃蛋白酶原Ⅰ(PGⅠ)、胃蛋白酶原Ⅱ(PGⅡ)水平低于常规组(P<0.05)。两组治疗期间的不良反应总发生率无显著差异(P>0.05)。结论抗Hp四联疗法治疗糖尿病合并Hp感染患者可获得理想效果,能有效降低血糖与炎性因子水平,调节胃功能,且不会增加药物不良反应。

Objective To analyze the application effect of anti-Helicobacter pylori(Hp)quadruple therapy in patients with diabetes mellitus complicated with Hp infection and its influences on serum inflammatory factors levels.Methods A total of 110 patients with diabetes mellitus complicated with Hp infection diagnosed and treated in Baoji Second People's Hospital and Baoji Central Hospital from April 2021 to May 2022 were selected as the research objects.The patients were randomly divided into routine group(55 cases,symptomatic treatment)and observation group(55 cases,anti-Hp quadruple therapy).The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was significantly higher than that in the routine group(P<0.05).After treatment,the levels of fasting plasma glucose(FPG)and 2 h postprandial blood glucose(2 h PG)in the observation group were significantly lower than those in the routine group(P<0.05).After treatment,the levels of C-reactive protein(CRP),interleukin-6(IL-6),procalcitonin(PCT),white blood cell count(WBC),gastrin-17(G-17),pepsinogenⅠ(PGⅠ)and pepsinogenⅡ(PGⅡ)in the observation group were lower than those in the routine group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups during treatment(P>0.05).Conclusion Anti-Hp quadruple therapy can achieve ideal results in the treatment of patients with diabetes mellitus complicated with Hp infection,which can effectively reduce the levels of blood glucose and inflammatory factors,regulate gastric function,and not increase adverse drug reactions.