米诺环素联合丁香油对急性可复性牙髓炎患者疼痛程度及牙髓活力的影响

Effects of minocycline combined with clove oil on pain degree and pulp vitality in patients with acute reversible pulpitis

目的探讨米诺环素联合丁香油对急性可复性牙髓炎患者疼痛程度及牙髓活力的影响。方法选取2021年1月至12月收治的100例急性可复性牙髓炎患者,以随机数字表法将其分为常规组(50例,丁香油)和观察组(50例,米诺环素联合丁香油)。比较两组的治疗效果。结果观察组的治疗总有效率高于常规组(P<0.05)。治疗后,观察组的前列腺素E_(2)(PGE_(2))、白三烯B4(LTB4)、白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)及肿瘤坏死因子-α(TNF-α)水平低于常规组(P<0.05)。治疗后,观察组的链球菌、葡萄球菌、奈瑟菌、小韦荣球菌、产黑色素类厌氧杆菌数量少于常规组(P<0.05)。治疗3、7、14 d后,观察组的视觉模拟评分法(VAS)评分低于常规组(P<0.05)。两组的不良反应总发生率无明显差异(P>0.05)。结论米诺环素联合丁香油治疗急性可复性牙髓炎患者可有效恢复牙髓活力,减轻炎症反应,缓解患者疼痛程度,且不会增加不良反应。

Objective To investigate the effects of minocycline combined with clove oil on pain degree and pulp vitality in patients with acute reversible pulpitis.Methods A total of 100 patients with acute reversible pulpitis admitted from January to December 2021 were selected and divided into conventional group(50 cases,clove oil)and observation group(50 cases,minocycline combined with clove oil)by random number table method.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was higher than that in the conventional group(P<0.05).After treatment,the levels of prostaglandin E_(2)(PGE_(2)),leukotriene B4(LTB4),interleukin-1β(IL-1β),interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)in the observation group were lower than those in the conventional group(P<0.05).After treatment,the number of Streptococcus,Staphylococcus,Neisseria,Veillonella parvula,Anaerobic bacilli producing melanin in the observation group were less than those in the conventional group(P<0.05).After 3,7 and 14 d of treatment,the Visual Analogue Scale(VAS)score of the observation group was lower than that of the conventional group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Minocycline combined with clove oil in the treatment of patients with acute reversible pulpitis can effectively restore pulp vitality,reduce inflammation,relieve pain degree,and will not increase adverse reactions.