孕期血清25(OH)D水平与子痫前期相关性的研究进展

Research Progress on the Correlation Between Serum^(2)5(OH)D Level and Preeclampsia During Pregnancy

妊娠期高血压疾病(hypertensive disorders of pregnancy,HDP)是继产后出血导致孕产妇死亡的第二大原因,严重威胁母婴身体健康。至今其发病机制尚未完全阐明,主要与子宫的螺旋小动脉重铸不足、炎症免疫过度激活、血管内皮细胞受损等有关。维生素D(Vitamin D,VitD)作为人体必需的维生素之一,其缺乏引起HDP的机制虽尚不明确,但有研究指出VitD在子痫前期的第一、二阶段均发挥相应作用,其可改善胚胎植入、胎盘发育和母体对同种异体移植物的耐受性,通过抑制炎症反应、降低氧化应激等作用拮抗子痫前期。子痫前期临床治疗手段相对有限,采取积极的预防干预,对相关高风险人群进行全面的管控预防,可以延缓疾病的发展,改善妊娠结局。

Hypertensive disorders of pregnancy(HDP)is the second leading cause of maternal death after postpartum hemorrhage,which seriously threatens the health of mother and child.Today its pathogenesis has not been fully elucidated,mainly small and uterine spiral artery recasting is insufficient,excessive inflammatory immune activation,endothelial cell damage and so on.Vitamin D(Vitamin D,VitD)as one of essential vitamins,its lack of cause mechanism of HDP,though it is not clear,but studies have pointed out that VitD in both the first and second stages of preeclampsia play a corresponding role,it can improve the embryo,the placenta and mother of allogeneic graft tolerance,It can antagonize preeclampsia by inhibiting inflammation and reducing oxidative stress.The clinical treatment of preeclampsia is relatively limited.Active prevention and intervention and comprehensive control and prevention of high-risk groups can delay the development of the disease and improve the pregnancy outcome.