乳杆菌与产丁酸盐菌交叉喂养调节肠道菌群紊乱的研究进展

Research Progress of Cross-feeding of Lactobacilli and Butyrate-producing Bacteria to Regulate Intestinal Microbiota Disorders

肠道菌群是近年的研究热点之一,其可以调节宿主生理和病理生理,影响消化系统、免疫系统、神经系统等功能,是健康肠道的基础。乳杆菌、双歧杆菌等益生菌在临床上被广泛用于调节肠道菌群,其可以增加肠道有益菌的数量。肠道有益菌可以抑制有害菌的生长,强化肠道屏障,减轻炎症反应。交叉喂养是细菌间的一种普遍且重要的相互作用方式。因此,深入认识乳杆菌促进肠道产丁酸盐菌生长的作用有助于进一步探讨乳杆菌调节肠道菌群紊乱的机制。

The gut microbiota is one of the research hotspots in recent years,which can regulate the host physiology and pathophysiology,affect digestive system,immune system,nervous system and other functions,and is the foundation of a healthy gut.Probiotics such as Lactobacillus and Bifidobacterium are widely used in the clinical practice to regulate the gut microbiota,which can increase the number of beneficial bacteria in the intestine.Beneficial bacteria in the intestine can inhibit the growth of harmful bacteria,strengthen the intestinal barrier,and alleviate inflammatory reactions.Cross-feeding is a common and important way of interaction between bacteria.Therefore,a deeper understanding of the role of lactobacilli in promoting the growth of butyrate-producing bacteria in the gut can help further explore the mechanism by which lactobacilli regulate gut microbiota disorders.