微RNA在脑胶质瘤早期诊断中的研究进展

Research Progress of MicroRNA in Early Diagnosis of Glioma

脑胶质瘤是最常见的原发性恶性脑肿瘤,具有高侵袭性和高复发性。随着肿瘤转移和侵袭性行为的加剧,患者的预后显著恶化。微RNA(miRNA)在脑胶质瘤的发生发展、血管生成、细胞侵袭和迁移以及化疗耐药性中发挥生物学作用,且具有作为诊断、预测患者预后和疾病复发风险的新型生物标志物的潜力。然而,miRNA的稳定性和特异性仍需进一步验证。未来研究应聚焦于miRNA的生物标志物验证、机制研究及其在临床诊断中的应用,以提高早期诊断的准确性和可靠性。

Glioma is the most common primary malignant brain tumor,with high invasiveness and recurrence.As the metastasis and invasive behavior of tumors intensify,the prognosis of patients significantly deteriorate.MicroRNA(miRNA)plays biological roles in the occurrence,development,angiogenesis,cell invasion and migration,and chemotherapy resistance of glioma,and have the potential to serve as novel biomarkers for the diagnosis,prediction of patient prognosis and disease recurrence risk.However,the stability and specificity of miRNA still need further validation.Future research should focus on the validation of miRNA biomarkers,mechanism studies,and their application in the clinical diagnosis to improve the accuracy and reliability of early diagnosis.