复方骨肽注射液对老年骨质疏松性胸腰椎压缩性骨折患者的影响

Effect of Compound Ossotide Injection on Elderly Patients with Osteoporotic Thoracolumbar Compression Fracture

目的:探究复方骨肽注射液对老年骨质疏松性胸腰椎压缩性骨折患者的影响。方法:选取2022年1月—2023年1月云梦县人民医院收治的82例老年骨质疏松性胸腰椎压缩性骨折手术患者。根据随机数表法分成两组,各41例。对照组术后给予碳酸钙D3片及阿法骨化醇软胶囊,观察组在对照组基础上给予复方骨肽注射液。比较两组术前及术后1个月骨代谢指标,术前及术后3 d炎症因子及疼痛介质,骨折愈合时间,术前及术后3个月腰椎功能。结果:术后1个月,观察组Ⅰ型胶原羧基末端肽β特殊序列(β-CTX)低于对照组,Ⅰ型前胶原氨基端前肽(PⅠNP)高于对照组,差异有统计学意义(P<0.05)。术后3 d,观察组白细胞介素-2(IL-2)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)均低于对照组,差异有统计学意义(P<0.05)。术后3 d,观察组前列腺素E2(PGE2)、P物质(SP)均低于对照组,差异有统计学意义(P<0.05)。术后3个月,观察组Oswestry功能障碍指数(ODI)评分低于对照组,骨折愈合时间短于对照组,差异有统计学意义(P<0.05)。结论:复方骨肽注射液有利于减轻老年骨质疏松性胸腰椎压缩性骨折手术患者的疼痛反应和炎症反应,改善患者的骨代谢,进而有利于患者术后腰椎功能的恢复。

Objective:To investigate the effect of Compound Ossotide Injection on elderly patients with osteoporotic thoracolumbar compression fracture.Method:A total of 82 elderly patients with osteoporotic thoracolumbar compression fracture treated in People's Hospital of Yunmeng County from January 2022 to January 2023 were selected.They were divided into two groups according to random number table method,41 cases in each group.The control group was given Calcium Carbonate D3 Tablets and Alfacalcidol Soft Capsules after operation,and the observation group was given Compound Ossotide Injection on the basis of the control group.Bone metabolism indexes before and 1 month after operation,inflammatory factors and pain mediators before and 3 d after operation,fracture healing time,and lumbar function before and 3 months after operation were compared between the two groups.Result:One month after operation,the carboxyl terminal peptide of type I collagen Beta special sequence(β-CTX)in observation group was lower than that of control group,and the amino terminal propeptide of typeⅠprocollagen(PⅠNP)was higher than that of control group,the differences were statistically significant(P<0.05).At 3 d after operation,interleukin-2(IL-2),interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)in observation group were lower than those in control group,and the difference was statistically significant(P<0.05).At 3 d after operation,prostaglandin E2(PGE2)and substance P(SP)in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).At 3 months after operation,the Oswestry disability index(ODI)score of the observation group was lower than that of the control group,and the fracture healing time was shorter than that of the control group,the differences were statistically significant(P<0.05).Conclusion:Compound Ossotide Injection is beneficial to alleviate pain and inflammation reaction in elderly patients with osteoporotic thoracolumbar compression fractures,improve bone metabolism,and then facilitate the recovery of lumbar function after surgery of patients.